AI Article Synopsis
- Alzheimer's Disease (AD) is a leading cause of dementia among older adults, and research indicates that neurons made from patient-derived induced pluripotent stem cells (iPSCs) can mimic key features of the disease, like tau phosphorylation and amyloid beta deposition.
- Researchers created a group of iPSC lines from two sporadic AD patients and three healthy controls, all derived from skin cells (dermal fibroblasts).
- The produced iPSC lines displayed normal chromosome patterns, expressed stem cell markers, and successfully differentiated into cells from all three germ layers (endoderm, mesoderm, and ectoderm).
Article Abstract
Alzheimer's Disease (AD) is the major cause of dementia in the elderly, and cortical neurons differentiated from patient-derived induced pluripotent stem cells (iPSCs) can recapitulate disease phenotypes such as tau phosphorylation or amyloid beta (Aß) deposition. Here we describe the generation of an iPSC cohort consisting of 2 sporadic AD cases and 3 controls, derived from dermal fibroblasts. All lines were karyotypically normal, showed expression of stem cell markers and efficiently differentiated into cells of all three germ layers.
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| http://dx.doi.org/10.1016/j.scr.2018.11.012 | DOI Listing |
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