AI Article Synopsis
- The study explored the link between two genetic variants (SNPs) in the GRM7 gene and schizophrenia among an Iranian population.
- The findings showed that one variant (rs779867) had a significantly lower frequency in schizophrenic patients compared to healthy controls, suggesting a potential protective effect against the disorder.
- However, no significant association was found for the second variant (rs6782011), reinforcing the role of GRM7 in schizophrenia's development rather than in treatment response.
Article Abstract
The role of metabotropic glutamate receptors in the pathogenesis of schizophrenia or response to antipsychotic treatment has been proposed previously. The aim of the current study was to investigate the associations between two intronic variants within GRM7 gene (rs6782011 and rs779867) and schizophrenia in Iranian population. These two single nucleotide polymorphisms (SNPs) were genotyped in 273 schizophrenic patients and 300 age and sex-matched normal controls. The frequency of A allele of the rs779867 was significantly lower in the schizophrenic patients compared with healthy subjects (OR (95% CI) = 0.71 (0.56-0.89), adjusted P value = 0.008). This SNP was associated with schizophrenia in co-dominant and dominant models (adjusted P values of 0.03 and 0.02 respectively). However, there was no difference in allele and genotype frequencies of the rs6782011 SNP between cases and controls. Consequently, the results of current study further highlight the participation of GRM7 in the pathogenesis of schizophrenia.
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| http://dx.doi.org/10.1007/s11011-018-0380-6 | DOI Listing |
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