Chavibetol corrects thyrotoxicosis through alterations in thyroid peroxidase.

Naunyn Schmiedebergs Arch Pharmacol

School of Life Sciences, Devi Ahilya University, Indore, India.

Published: May 2019

AI Article Synopsis

  • Thyrotoxicosis is a condition caused by excess thyroid hormones, affecting various body systems and leading to serious health risks if untreated.
  • In this study, chavibetol, a compound from Piper betel leaves, was tested for its effects on rats with induced thyrotoxicosis using L-thyroxine (L-T).
  • Chavibetol treatment showed significant improvements in thyroid function and tissue health, comparable to the effects of a conventional antithyroid drug, propylthiouracil (PTU).

Article Abstract

Thyrotoxicosis is a clinical syndrome that commonly results from excess secretion and/or release of thyroid hormones in the circulation. It affects most of the body systems and if not treated properly may lead to serious health problems. In this investigation, we isolated a phenolic compound, chavibetol (CHV) from Piper betel leaf and evaluated its possible ameliorative effects in thyrotoxicosis of rats. Adult female rats were rendered thyrotoxic by the administration of L-thyroxine (L-T) at 500 μg/kg/day, i.p., for 12 days, and then chavibetol (20.0 mg/kg, p.o.) was administered for 2 weeks. L-T administration elevated the concentration of serum thyroxine and triiodothyronine, activities of alanineaminotransferase and aspartate aminotransferase, and decreased the thyrotropin level as well as the expression of thyroid peroxidase (TPO). Further, it increased the activities of hepatic 5'mono-deiodinase-I, glucose-6--phosphatase, sodium-potasium-ATPase, and lipid peroxidation, and depleted the cellular antioxidants. However, chavibetol treatment to thyrotoxic rats normalized almost all these indices including TPO and also preserved the integrity of thyroid tissues suggesting its potential to correct thyrotoxicosis. Effects of CHV were more or less similar to a conventional antithyroid drug, propylthiouracil (PTU).

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http://dx.doi.org/10.1007/s00210-018-01606-xDOI Listing

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