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BAY 2413555 is a novel selective and reversible positive allosteric modulator of the type 2 muscarinic acetylcholine (M2) receptor, aimed at enhancing parasympathetic signaling and restoring cardiac autonomic balance for the treatment of heart failure (HF). This study tested the safety, tolerability and pharmacokinetics of this novel therapeutic option. REMOTE-HF was a multicenter, double-blind, randomized, placebo-controlled, phase Ib dose-titration study with two active arms.
View Article and Find Full Text PDFImmunological characterization of pleural effusions in pediatric patients.
Front Immunol
December 2024
Department of General Pediatrics and Neonatology, Saarland University, Campus Homburg, Homburg, Germany.
Background: The pleural cavity represents a unique immunological compartment that can mount inflammatory reactions during infections, after surgery and in chronic immunological diseases. The connection between systemic immune reactions in the blood and local immune reactions in pleural effusions remains unclear. This study provides the first comprehensive immunological characterization of paired blood and pleural effusion samples, utilizing combined cell and cytokine analyses in pediatric patients undergoing cardiac surgery.
View Article and Find Full Text PDFChildhood obesity in South Asian population.
Obes Pillars
December 2024
Dr L H Hiranandani Hospital, India.
Introduction: Obesity is worldwide health concern, with its prevalence rising steeply specially in low and middle-income countries in the past decade. World Obesity Federation estimates that one in five women and one in seven men - will be obese by 2030.Obesity numbers are expected to double during same year in South and South Asian countries, with obesity in children over age of five estimated to be at forty-five million.
View Article and Find Full Text PDFDouble-barrel coronary sinus: a rare anomaly unveiled during cardiac resynchronization therapy.
Coron Artery Dis
October 2024
Department of Cardiology, Kocaeli City Hospital, Kocaeli, Turkey.
The First Report of Cod Gill Poxvirus in Gills of Atlantic Cod (Gadus morhua L.) Suffering From Cardiorespiratory Disease.
J Fish Dis
December 2024
Department of Fish Health and Biosecurity, Norwegian Veterinary Institute, Oslo, Norway.
Atlantic cod farming experiences renewed growth in Norway, and increased awareness is essential to address emerging diseases in this species. There are few reports on gill diseases in cod, and to date, no viral gill infections of cod have been documented. In this study, we collected samples from three sequential time points in summer 2023 from farmed cod suffering from cardiorespiratory disease.
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