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Identification and characterisation of hypomethylated DNA loci controlling quantitative resistance in . | LitMetric

AI Article Synopsis

  • - The study explores how plants can inherit traits through variations in DNA methylation rather than changes to the DNA sequence, focusing on epigenetic recombinant inbred lines (epiRILs) for disease resistance.
  • - Researchers identified four specific regions, known as epigenetic quantitative trait loci (epiQTLs), that contribute to disease resistance without harming overall plant growth or their ability to withstand other stresses.
  • - Findings suggest that lower levels of DNA methylation in certain pericentromeric regions lead to enhanced activation of defense genes early during infections, highlighting potential mechanisms for improved disease resistance in plants.

Article Abstract

Variation in DNA methylation enables plants to inherit traits independently of changes to DNA sequence. Here, we have screened an population of epigenetic recombinant inbred lines (epiRILs) for resistance against . These lines share the same genetic background, but show variation in heritable patterns of DNA methylation. We identified four epigenetic quantitative trait loci (epiQTLs) that provide quantitative resistance without reducing plant growth or resistance to other (a)biotic stresses. Phenotypic characterisation and RNA-sequencing analysis revealed that resistant epiRILs are primed to activate defence responses at the relatively early stages of infection. Collectively, our results show that hypomethylation at selected pericentromeric regions is sufficient to provide quantitative disease resistance, which is associated with genome-wide priming of defence-related genes. Based on comparisons of global gene expression and DNA methylation between the wild-type and resistant epiRILs, we discuss mechanisms by which the pericentromeric epiQTLs could regulate the defence-related transcriptome.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342528PMC
http://dx.doi.org/10.7554/eLife.40655DOI Listing

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