[Ontogenetic characteristics of patients with erectile dysfunction with different types of aging.].

Age-related erectile dysfunction (ED) can be formed during ontogenesis in accordance with various mechanisms of the pathogenesis of aging in conjunction with a particular cluster of diseases. The aim of the work is to study ontogenetic features of ED patients in late ontogeny of various types of aging. 65 men over 45 with an explicit form of ED were examined. The first group consisted of patients with general-somatic diseases (GSD) arising mainly from the accumulation model of aging, and the second group included patients with age-associated diseases (AAD), arising primarily from the ontogenetic model of aging. Both variants of age-related ED are closely related to ontogenetic events, especially with the debut of obesity and the loss of morning erections, preceding the ED debut, on average over a decade of life. ED, combined with AAD, is most clinically and pathogenetically compromised. Thus, it is characterized by: earlier age of debut ED, dismetabolic pattern, low geroprotective pattern, poor quality of primary health, pronounced instability of gonadostat, weak sexual constitution, decreased sensitivity of hypothalamic-pituitary complex to feedback signals, the large proliferative pattern. ED associated with GSD had a later age of debut ED, developed much later from the debut of obesity, had a lower level of testicular volume with a more conserved incretory function, but a higher index of IPSS. Thus, the separation of two ED variants associated with different types of aging in conjunction with the use of ontogenetic analysis, allowed to identify significant differences in such clinical and pathogenetic forms, which is important for the development of ideas about the diagnosis and treatment of age-related ED.