Management of early- and late-onset sepsis: results from a survey in 80 German NICUs.

Infection

Department of Pediatric Hematology and Oncology, Children's Hospital Medical Center, University Hospital of Saarland, Gebäude 9, Kirrberger Straße, 66421, Homburg/Saar, Germany.

Published: August 2019

Purpose: The management of early- (EOS) and late-onset sepsis (LOS) and neonatal intensive care units (NICUs) has not been extensively evaluated.

Methods: 231 highly specialized level 1 and level 2 NICUs in Germany were asked to participate in an internet-based survey.

Results: The final analysis of anonymized datasets from 80 NICUs (response rate 34.6 %) compared university hospitals and regional neonatal referral centers. The survey describes potential areas of improvement concerning empirical treatment of infants with LOS with vancomycin and 3rd generation cephalosporins, minimal volume of blood sampling for aerobic culture, consideration of lumbar tap in any child with blood culture positive LOS and drug monitoring details for gentamicin and vancomycin.

Conclusion: In summary, this survey reveals a significant gap between recent national German guidelines and daily practices in German NICUs.

Download full-text PDF

Source
http://dx.doi.org/10.1007/s15010-018-1263-9DOI Listing

Publication Analysis

Top Keywords

management early-
8
late-onset sepsis
8
german nicus
8
nicus
5
early- late-onset
4
sepsis survey
4
survey german
4
nicus purpose
4
purpose management
4
early- eos
4

Similar Publications

The study was designed to appraise the effects of early antibiotic administration on reproductive tract infections and fetal membrane cell scorching in instances of premature rupture of membranes (PROM). A total of 107 pregnant women diagnosed with PROM between July 2020 and June 2022 were randomly assigned to two groups: the Intervention (n=54), where ampicillin were administered within 24 hours of PROM onset, and the control group (n=53), where ampicillin were given 24-48 hours after PROM. Maternal and neonatal outcomes, incidence of reproductive tract infections, and fetal membrane cell scorching indicators (Caspase-1, Caspase -3, Caspase-9 and IL-β) were compared.

View Article and Find Full Text PDF

In this study, we introduce a novel approach that integrates interpretability techniques from both traditional machine learning (ML) and deep neural networks (DNN) to quantify feature importance using global and local interpretation methods. Our method bridges the gap between interpretable ML models and powerful deep learning (DL) architectures, providing comprehensive insights into the key drivers behind model predictions, especially in detecting outliers within medical data. We applied this method to analyze COVID-19 pandemic data from 2020, yielding intriguing insights.

View Article and Find Full Text PDF

A Signal-On Microelectrode Electrochemical Aptamer Sensor Based on AuNPs-MXene for Alpha-Fetoprotein Determination.

Sensors (Basel)

December 2024

Innovation Platform of Micro/Nano Technology for Biosensing, ZJU-Hangzhou Global Scientific and Technological Innovation Center, Zhejiang University, Hangzhou 311200, China.

As a crucial biomarker for the early warning and prognosis of liver cancer diseases, elevated levels of alpha-fetoprotein (AFP) are associated with hepatocellular carcinoma and germ cell tumors. Herein, we present a novel signal-on electrochemical aptamer sensor, utilizing AuNPs-MXene composite materials, for sensitive AFP quantitation. The AuNPs-MXene composite was synthesized through a simple one-step method and modified on portable microelectrodes.

View Article and Find Full Text PDF

Bladder cancer is one of the most common cancers worldwide. Despite its high incidence, cystoscopy remains the currently used diagnostic gold standard, although it is invasive, expensive and has low sensitivity. As a result, the cancer diagnosis is mostly late, as it occurs following the presence of hematuria in urine, and population screening is not allowed.

View Article and Find Full Text PDF

Small Gap Dynamics in High Mountain Central European Spruce Forests-The Role of Standing Dead Trees in Gap Formation.

Plants (Basel)

December 2024

Department of Forest Resource Planning and Informatics, Faculty of Forestry, Technical University in Zvolen, T. G. Masaryka 24, 960 01 Zvolen, Slovak Republic.

Gap dynamics are driving many important processes in the development of temperate forest ecosystems. What remains largely unknown is how often the regeneration processes initialized by endogenous mortality of dominant and co-dominant canopy trees take place. We conducted a study in the high mountain forests of the Central Western Carpathians, naturally dominated by the Norway spruce.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!