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We present the case of a 60-year-old patient who underwent a complicated cataract surgery with cefuroxime injection (1 mg/0.1 mL) into the anterior chamber at the end of surgery. The patient presented to our hospital due to decrease in visual acuity (VA) after surgery. VA was counting fingers (CF) from 4 meters. There was extensive retinal hemorrhages and edema in addition to retinal vascular leakage detected with fluorescein angiography (FA). After negative microbiologic tests, the patient was treated with intravenous pulse and oral corticosteroids. Rheumatologic investigation was also negative. At month 5, VA was CF from 1 meter in addition to disseminated capillary loss in FA and optic nerve atrophy despite corticosteroid treatment. The patient developed retinal infarction due to cefuroxime injection following a complicated cataract surgery. Surgeons and surgical staff should be aware of the possibility of retinal toxicity while using cefuroxime, particularly in complicated cases.
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http://dx.doi.org/10.4274/tjo.61580 | DOI Listing |
J Allergy Clin Immunol Pract
November 2024
Division of Allergic Diseases, Department of Internal Medicine, Mayo Clinic, Rochester, Minn.
Background: Maximal skin testing (ST) nonirritant concentrations (NICs) are consistent for penicillin and aminopenicillin among guidelines. However, there is variability among guidelines for maximal ST NICs of cephalosporins.
Objective: To determine maximal immediate and delayed ST NICs of 15 β-lactams in β-lactam-tolerant and β-lactam-naïve participants.
Ther Adv Drug Saf
June 2024
School of Pharmacy, Hangzhou Medical College, Hangzhou, Zhejiang, China.
Microbiol Spectr
July 2024
Department of Mycobacterium Reference and Research, Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association, Tokyo, Japan.
Zhonghua Yan Ke Za Zhi
May 2024
Xiamen Eye Center of Xiamen University, Fujian Provincial Key Laboratory of Ocular Surface & Corneal Diseases, Xiamen Municipal Key Laboratory of Ocular Surface & Corneal Diseases, Xiamen Municipal Key Laboratory of Ocular Diseases, Xiamen Clinical Research Center for Eye Diseases, Xiamen 361002, China.
A 36-year-old male patient presented with a decrease in vision after undergoing scleral suturing for a left eye injury caused by an iron hook, combined with intravitreal injection of cefuroxime. Ocular examination revealed extensive gray-white edematous areas in the macular region, along with focal serous shallow retinal detachment in the posterior pole. Following admission, comprehensive ophthalmic examinations were conducted, leading to the diagnosis of toxic retinal damage in the left eye.
View Article and Find Full Text PDFBull Environ Contam Toxicol
April 2024
Polytechnic University of the Metropolitan Area of Guadalajara, Av. Adolf Bernard Horn Junior 8941, Cajititlán, C.P. 45670, México.
To date, there is an increased risk to public health and the environment due to the presence of pharmaceutically active compounds within drinking water supply and distribution networks. Owing to this, a direct injection-HPLC/MS-MS method was developed for the simultaneous determination of 16 active pharmaceutical compounds in tap water samples: amoxicillin, ampicillin, cephalexin, cefotaxime, cefuroxime, ciprofloxacin, clarithromycin, clindamycin, chloramphenicol, cyproterone, erythromycin, flutamide, spironolactone, sulfamethoxazole, tamoxifen, and trimethoprim. Limits of detection (LOD) ranged from 0.
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