Obesity and its complications are one of the biggest problems that a clinician faces today. The vast majority of the treatments implemented have low effcacy, and obesity becomes diffcult to manage. In the last decades, obesity prevalence has doubled. A new perspective to deal with it was becoming important. Obesity ceased to be considered a clearly metabolic disease. The objective of this review was to look for the similarities of the obese patient's clinic with addiction of substances and addictive behaviors. For which a search was done on the Pubmed and Scielo databases using the terms "addiction", "food craving", "obesity", "saciety" and "serotonin" given the evidences that link this neurotransmitter with reward and saciety mechanisms. We synthetize the observations published in sixteen reviews obtained in this search. Considering obesity as an addictive disorder or substance dependence disorder allows us not to be shipwrecked in the search for a unique psychological or physiological specifer and to approach the problem from another perspective. At the same time, it cushions the impact of the stigma that the morbid obese patient experiences as responsible for his illness.
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Cureus
December 2024
General Surgery, Universidad de Monterrey, San Pedro Garza García, MEX.
Obesity has been regarded as an epidemic in recent years. Various treatments have been developed, with bariatric surgery showing the highest levels of safety and effectiveness. This has increased its popularity and demand not only among young adults but also among elderly patients.
View Article and Find Full Text PDFCureus
December 2024
Department of Family Medicine, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Jeddah, SAU.
Objectives This study analyzed the practices and findings on postpartum type 2 diabetes mellitus (T2DM) screening among pregnant women with gestational diabetes mellitus (GDM). Methods A retrospective cohort study was conducted at a tertiary care center in Western Saudi Arabia, between January 1, 2016, and December 31, 2018. It involved 642 nondiabetic women with a confirmed diagnosis of GDM, who were followed until delivery.
View Article and Find Full Text PDFJ Taibah Univ Med Sci
December 2024
Department of Veterinary Pre-Clinical Science, Faculty of Veterinary Medicine, Universiti Putra Malaysia, Serdang, Selangor, Malaysia.
Objective: Concerns over the increasing number of obese individuals and the associated health risks have prompted therapeutic option explorations. Similarly, this study aimed to establish fruit extract (SCFE) anti-adipogenic attributes in 3T3-L1 cells.
Methods: The polyphenolic compounds in SCFE were identified with Reverse phase-high performance liquid chromatography (RP-HPLC).
Acta Pharm Sin B
December 2024
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Nuclear receptor corepressor (NCoR1) interacts with various nuclear receptors and regulates the anabolism and catabolism of lipids. An imbalance in lipid/energy homeostasis is also an important factor in obesity and metabolic syndrome development. In this study, we found that the deletion of NCoR1 in intestinal epithelial cells (IECs) mainly activated the nuclear receptor PPAR and attenuated metabolic syndrome by stimulating thermogenesis.
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