AI Article Synopsis
- - This study is the first to show that menstrual blood-derived stem cells (MenSCs) can effectively promote skin wound healing when transplanted using decellularized human amniotic membrane (DAM).
- - In the experiment, MenSCs were added to DAM at a specific density and then implanted in rats with full-thickness skin wounds.
- - The findings revealed that the MenSC-seeded DAM led to significantly better wound closure and healing compared to the DAM alone, suggesting MenSCs could be a promising option for treating skin injuries.
Article Abstract
This is the first study demonstrating the efficacy of menstrual blood-derived stem cell (MenSC) transplantation via decellularized human amniotic membrane (DAM), for the promotion of skin excisional wound repair. The DAM was seeded with MenSCs at the density of 3 × 10 cells/cm and implanted onto a rat's 1.50 × 1.50 cm full-thickness excisional wound defect. The results of wound closure and histopathological examinations demonstrated that the MenSC-seeded DAM could significantly improve the wound healing compared with DAM-treatment. All in all, our data indicated that the MenSCs can be a potential source for cell-based therapies to regenerate skin injuries.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209087 | PMC |
| http://dx.doi.org/10.1007/s13534-018-0084-1 | DOI Listing |
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