AI Article Synopsis
- - Integrins are crucial adhesion molecules that help cells stick to the extracellular matrix, playing a vital role in embryonic development and various diseases like inflammation and cancer.
- - This article reviews how proteins like talin and kindlin, along with mechanical forces, affect the binding strength and overall effectiveness (affinity and avidity) of integrins.
- - It also explores the role of integrin inactivators within this system, shedding light on their potential impact on cell behavior and disease progression.
Article Abstract
Integrins are the major family of adhesion molecules that mediate cell adhesion to the extracellular matrix. They are essential for embryonic development and influence numerous diseases, including inflammation, cancer cell invasion and metastasis. In this Perspective, we discuss the current understanding of how talin, kindlin and mechanical forces regulate integrin affinity and avidity, and how integrin inactivators function in this framework.
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| http://dx.doi.org/10.1038/s41556-018-0234-9 | DOI Listing |
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