AI Article Synopsis
- Nontuberculous mycobacteria (NTM) primarily affect patients with existing lung issues, and new compounds called indole-2-carboxamides (ICs) have shown effectiveness against these pathogens.
- Two specific lead molecules, referred to as compounds 5 and 25, were tested in mouse models infected with NTM.
- When administered orally, these lead molecules significantly reduced the bacterial levels in the lungs and spleens of the infected mice.
Article Abstract
Nontuberculous mycobacteria (NTM) pathogens particularly infect patients with structural lung disorders. We previously reported novel indole-2-carboxamides (ICs) that are active against a wide panel of NTM pathogens. This study discloses data for two lead molecules (compounds 5 and 25) that were advanced for efficacy studies in -infected mouse models. Oral administration of the lead molecules showed a statistically significant reduction in the bacterial loads in lung and spleen of -infected mice.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395937 | PMC |
| http://dx.doi.org/10.1128/AAC.02245-18 | DOI Listing |
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