The process of systematically developing a sustainability vision is an important element of effective environmental management. Sustainability visions can, however, include contradictions and counterintuitive effects due to complex system behavior (e.g., feedback loops, multi-causality) and ambiguous system boundaries (e.g., choice of a scale, such as a regional or national scale). This paper proposes an innovative methodological framework for vision design and assessment (VDA) to analyze the sustainability of future visions on multiple scales with consideration of ecosystem services, and to test their plausibility based upon expert and local knowledge. First, requirements and functions of visionary system designs are identified. Second, a functional organizational analysis defines structures and processes that generate functions. Third, a literature review and participatory modeling process are conducted to analyze the system structures of visionary system designs using causal loop diagrams. Fourth, fuzzy cognitive mapping is used to assess visions based upon sustainability indicators. A case study on sustainable food systems in Southwestern Ontario, Canada, is provided to demonstrate the application of the methodology. Three designs of a sustainable food system were analyzed and tested: urban organic gardening, a local diversified organic food system and a globalized commodity-based organic food system. The results show the advantages and disadvantages of each system design and underline the sustainability benefits of a multi-scale food system based upon a combination of system designs.
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http://dx.doi.org/10.1016/j.jenvman.2018.09.099 | DOI Listing |
JMIR Res Protoc
January 2025
Department of Pediatrics, School of Medicine, University of Virginia, Charlottesville, VA, United States.
Background: Low back pain (LBP) is highly prevalent and disabling, especially in agriculture sectors. However, there is a gap in LBP prevention and intervention studies in these physically demanding occupations, and to date, no studies have focused on horticulture workers. Given the challenges of implementing interventions for those working in small businesses, self-management offers an attractive and feasible option to address work-related risk factors and manage LBP.
View Article and Find Full Text PDFDespite the EU legislation regulating the circulation of dietary and food supplements within the internal market, the system of state control requires improvement. For instance, due to existing regulatory gaps, certain pharmaceutical entities commit violations of regulatory requirements, such as failing to register medicinal products and selling them under the guise of dietary and/or food supplements. Conversely, physicians may recommend ordinary dietary and food supplements to patients as if they were medicinal products.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
February 2025
Department of Agricultural Biotechnology, and Research Institute of Agriculture and Life Sciences, CALS, Seoul National University, Seoul 08826, Republic of Korea.
The formation of superoxide dismutase 1 (SOD1) filaments has been implicated in amyotrophic lateral sclerosis (ALS). Although the disulfide bond formed between Cys57 and Cys146 in the active state has been well studied, the role of the reduced cysteine residues, Cys6 and Cys111, in SOD1 filament formation remains unclear. In this study, we investigated the role of reduced cysteine residues by determining and comparing cryoelectron microscopy (cryo-EM) structures of wild-type (WT) and C6A/C111A SOD1 filaments under thiol-based reducing and metal-depriving conditions, starting with protein samples possessing enzymatic activity.
View Article and Find Full Text PDFAdv Sci (Weinh)
January 2025
Hunan Provincial Key Laboratory of Animal Intestinal Function and Regulation, Hunan international joint laboratory of Animal Intestinal Ecology and Health, Laboratory of Animal Nutrition and Human Health, College of Life Sciences, Hunan Normal University, Changsha, 410081, China.
Aspartate (Asp) metabolism-mediated antioxidant functions have important implications for neonatal growth and intestinal health; however, the antioxidant mechanisms through which Asp regulates the gut microbiota and influences RIP activation remain elusive. This study reports that chronic oxidative stress disrupts gut microbiota and metabolite balance and that such imbalance is intricately tied to the perturbation of Asp metabolism. Under normal conditions, in vivo and in vitro studies reveal that exogenous Asp improves intestinal health by regulating epithelial cell proliferation, nutrient uptake, and apoptosis.
View Article and Find Full Text PDFEnviron Technol
February 2025
PGEAGRI/CCET - Center of Exact Sciences and Technology, State University of Western of Paraná - UNIOESTE, Cascavel, Brazil.
The deammonification process is an efficient alternative to remove nitrogen from wastewater with a low carbon/nitrogen ratio. However, the reactor configuration and operational factors pose challenges for applications in treatment systems to remove nitrogen from municipal and industrial wastewater on a large scale. To address this gap, this study evaluated a new deammonification strategy using a single-stage membrane aerated biofilm reactor (MABR), operated with continuous flow, under different hydraulic retention times (HRT) in the post-treatment of poultry slaughterhouse wastewater with a low nitrogen load, similar to domestic wastewater.
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