Study Objectives: Children with "restless sleep disorder" (RSD) were previously identified clinically and polysomnographically. In this study, we attempt to characterize their sleep-related movements and describe them in terms of type of movement, duration, and timing.
Methods: Video-polysomnography (vPSG) from 15 school-aged children with RSD, 15 sex- and age-matched children with restless legs syndrome (RLS), and 15 controls was reviewed for identification of sleep-related movements. Data obtained included the routine data collected during PSG and the video assessment of the movements which included time of the night when the movement occurred, type of movement (arms, legs, and body position change), and duration of the movement.
Results: vPSG recordings from 15 children with RLS (12 males, 3 females) with a mean age of 11.9 (SD: 3.52), 15 participants with RSD (11 males, 4 females) with a mean age of 9.5 (SD: 3.18), and 15 controls (9 males, 6 females) with a mean age of 10. The total movement index, obtained by summing together all types of movements in each participant and dividing it by the total sleep time, was prominent in children with RSD in all sleep stages. Five movements per hour gave 100% accuracy vs. controls and 90% vs. RLS. Movements occurred all night.
Conclusions: We have characterized the sleep-related movements of children with RSD in comparison to the movements in children with RLS and in controls. We identified that children with RSD move all night and an index of 5 per hour accurately separates RSD from other disorders.
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http://dx.doi.org/10.1093/sleep/zsy269 | DOI Listing |
Cell Rep
March 2025
Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX, USA; Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, 1250 Moursund St., Suite N.1150, Houston, TX, USA; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA. Electronic address:
Despite its significant heritability, the genetic basis of Parkinson's disease (PD) remains incompletely understood. Here, in analyzing whole-genome sequence data from 3,809 PD cases and 247,101 controls in the UK Biobank, we discover that protein-truncating variants in ITSN1 confer a substantially increased risk of PD (p = 6.1 × 10; odds ratio [95% confidence interval] = 10.
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March 2025
Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX, USA; Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA. Electronic address:
Despite great progress, thousands of neurodevelopmental disorder (NDD) risk genes remain to be discovered. We present a computational approach that accelerates NDD risk gene identification using machine learning. First, we demonstrate that models trained solely on single-cell RNA sequencing data can robustly predict genes implicated in autism spectrum disorder (ASD), developmental and epileptic encephalopathy (DEE), and developmental delay (DD).
View Article and Find Full Text PDFSci Rep
February 2025
Iranian Research Institute of Plant Protection (IRIPP), Agricultural Research, Education and Extension Organization (AREEO), Tehran, Iran.
In this study, 211 pesticides were analyzed simultaneously using a QuEChERS method coupled with GC-MS-MS and LC-MS-MS in 90 fresh date fruit samples produced in Kerman Province. Probabilistic estimates of non-carcinogenic and carcinogenic health risks were evaluated using Monte Carlo simulation-based hazard Quotient (HQ), hazard index (HI) and carcinogenic risk (CR). The linearity of 0.
View Article and Find Full Text PDFJ Sep Sci
January 2025
Department of Pharmaceutical Chemistry, Medical University of Gdańsk, Gdańsk, Poland.
Interest in obstructive sleep apnea is rising due to its neurocognitive and cardiovascular impacts, including systemic hypertension, myocardial infarction, and cerebrovascular events. Obstructive sleep apnea diagnosis can be suggested through symptoms like snoring, daytime sleepiness, and physical signs like increased neck circumference; however, overnight polysomnography is recommended to confirm. Exhaled breath condensate has emerged as a novel, noninvasive technique for biomarker sample collection.
View Article and Find Full Text PDFContext: Anemia is a medical condition resulting from a reduction in the number of red blood cells below the reference range. It is a major public health problem, particularly among adolescents, as it can have negative effects on cognitive performance, growth and reproduction. This study aims to assess the determinants of anemia among adolescents in schools in the city of Douala.
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