The study was carried out to investigate micro-ecological characteristics of intestinal microbiocenosis in children with functional disorders of gastro-intestinal tract. All patients were applied general clinical and laboratory examination (feces microscopy and analysis on intestinal dysbacteriosis). The micro-ecological coefficients were calculated i.e. permanence indicator and Jaccard's coefficient of community. The analysis of obtained data demonstrated that in children the risk factors of functional disorders of functioning of digestive organs are compromised heredity on diseases of digestive organs; frequent cold diseases; dysbiosis disorders in intestinal microbiota. In children with functional disorders of gastro-intestinal tract permanent microflora contained representatives of transitory opportunistic microflora entering into symbiotic relationships both with indigent microflora and with each other. The obtained data testify necessity of making in patients with functional disorders of digestive organs along with standard diagnostic procedures of evaluation of intestinal microflora. the reason is that main indices of micro-ecological balance of intestinal microbiota are important criteria reflecting severity of course of disease and effectiveness of applied treatment.
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Epidemiol Infect
January 2025
Health Protection Operations, South West, UK Health Security Agency, Bristol, UK.
In September 2023, the UK Health Security Agency's (UKHSA) South West Health Protection Team received notification of patients with perichondritis. All five cases had attended the same cosmetic piercing studio and a multi-disciplinary outbreak control investigation was subsequently initiated. An additional five cases attending the same studio were found.
View Article and Find Full Text PDFClin EEG Neurosci
January 2025
Palma Sola Neurology Associates, Bradenton, FL, USA.
Evoked potential metrics extracted from an EEG exam can provide novel sources of information regarding brain function. While the P300 occurring around 300 ms post-stimulus has been extensively investigated in relation to mild cognitive impairment (MCI), with decreased amplitude and increased latency, the P200 response has not, particularly in an oddball-stimulus paradigm. This study compares the auditory P200 amplitudes between MCI (28 patients aged 74(8)) and non-MCI, (35 aged 72(4)).
View Article and Find Full Text PDFAnn Neurol
January 2025
Department of Neurology, University of Massachusetts Chan Medical School, Worcester, MA.
Objective: Approximately 20% of familial cases of amyotrophic lateral sclerosis (ALS) are caused by mutations in the gene encoding superoxide dismutase 1 (SOD1). Epidemiological data have identified traumatic brain injury (TBI) as an exogenous risk factor for ALS; however, the mechanisms by which TBI may worsen SOD1 ALS remain largely undefined.
Methods: We sought to determine whether repetitive TBI (rTBI) accelerates disease onset and progression in the transgenic SOD1 mouse ALS model, and whether loss of the primary regulator of axonal degeneration sterile alpha and TIR motif containing 1 (Sarm1) mitigates the histological and behavioral pathophysiology.
Child Adolesc Ment Health
January 2025
School of Public Health, Southeast University, Nanjing, China.
Background: Animal-assisted interventions (AAIs) have emerged as a promising nonpharmacological intervention option for children diagnosed with attention-deficit/hyperactivity disorder (ADHD). However, recent systematic reviews have been primarily narrative. Additionally, the pooled effectiveness of AAIs was absent from these systematic reviews.
View Article and Find Full Text PDFHum Brain Mapp
January 2025
Center for MR Research, University Children's Hospital Zurich, Zurich, Switzerland.
The human brain connectome is characterized by the duality of highly modular structure and efficient integration, supporting information processing. Newborns with congenital heart disease (CHD), prematurity, or spina bifida aperta (SBA) constitute a population at risk for altered brain development and developmental delay (DD). We hypothesize that, independent of etiology, alterations of connectomic organization reflect neural circuitry impairments in cognitive DD.
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