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A mitochondria-targeted NIR fluorescence/photoacoustic dual-modality probe for highly sensitive and selective imaging of HClO in vivo.
Spectrochim Acta A Mol Biomol Spectrosc
December 2024
Department of Research & Clinical Laboratory, The Fifth Affiliated Hospital of Guangxi Medical University, The First People's Hospital of Nanning, Nanning 530022, Guangxi, PR China. Electronic address:
Article Synopsis
- Hypochlorous acid (HClO) is a reactive oxygen species produced in mitochondria, and its high levels are associated with various diseases, making its detection crucial in medicine.
- A new dual-modality probe called MB-ClO has been developed, which uses near-infrared fluorescence (NIRF) and photoacoustic (PA) imaging techniques to accurately and sensitively detect HClO in biological systems.
- MB-ClO shows low toxicity and good water solubility, has a fast response time, and has been successfully tested in a mouse model of rheumatoid arthritis, highlighting its potential for biomedical applications.
Rational Development of a Lipid Droplets and Hypochlorous Acid In-Sequence Responsive Fluorescent Probe for Accurate Imaging of Atherosclerotic Plaques.
Anal Chem
December 2024
Shandong Provincial Key Laboratory of Detection Technology for Tumor Markers, College of Chemistry and Chemical Engineering, Linyi University, Linyi 276000, China.
To answer the call for effective and timely intervention in cardiovascular diseases (CVDs), the development of fluorescent probes that can precisely identify atherosclerotic plaques, the root cause of various fatal CVDs, is highly desirable but remains a great challenge. Herein, by integrating bis(trifluoromethyl)benzyl and phenothiazine into the coumarin matrix, a robust fluorescent probe, NOR1, has been developed. NOR1 responds sequentially to lipid droplets (LDs) and HClO via fluorescence turn-on and ratiometric readouts, respectively, with a fast response rate (within 70 s for LDs and 80 s for HClO), excellent sensitivity (detection limit: 0.
View Article and Find Full Text PDFMyeloperoxidase enzyme-catalyzed breakdown of zero-dimension carbon quantum dots.
Front Med Technol
November 2024
Department of Biochemical Engineering, School of Chemical Engineering, Harcourt Butler Technical University, Kanpur, India.
Carbon quantum dots (CQDs) have shown considerable interest in multiple fields including bioimaging, biosensing, photocatalysis, ion sensing, heavy metal detection, and therapy due to highly tunable photoluminescence and good photostability. Apart from having optical properties CQDs offer several advantages such as low toxicity, environmental friendliness, affordability, and simple synthesis methods. Furthermore, by modifying their surface and functionality, it's possible to precisely control their physical and chemical characteristics.
View Article and Find Full Text PDFA fluorescence probe for monitoring toxic hypochlorous acid in biosystems and environmental waters with a broad pH adaptation.
Ecotoxicol Environ Saf
December 2024
State Key Laboratory of New Optical Functional Materials, Anyang Normal University, Anyang, Henan 455000, China; Department of Energy and Resource Engineering, College of Engineering, Peking University, Beijing 100871, China. Electronic address:
Hypochlorous acid (HOCl) is commonly utilized in various daily applications. As a toxic reactive oxygen species (ROS) that generated from the industrial and pharmaceutical aspects, it plays a critical role in the mass cycle of environmental system and various biological processes. Understanding the complicated roles of HOCl in environment and biosystems requires the development of precise and efficient detection methods.
View Article and Find Full Text PDFMonitoring electrophilic intermediates in reactions of thiols in aqueous solution directly with F NMR.
Chem Sci
December 2024
Department of Chemistry and Biomolecular Sciences, University of Ottawa 10 Marie Curie Pvt Ottawa ON K1N6N5 Canada
Mechanistic studies of thiol reactivity can be challenging because electrophilic reaction intermediates, such as sulfenic acids (RSOH) and sulfenyl chlorides (RSCl), are generally too reactive to be observed directly. Herein we report the design and synthesis of a sterically-encumbered fluorinated triptycene thiol which enables direct observation of reaction intermediates in aqueous buffer by F NMR, as demonstrated in reactions with hydrogen peroxide and hypochlorous acid. Reactions with HO resulted in the formation of a persistent RSOH species, which was subsequently converted to a sulfinic acid (RSOH) and then a sulfonic acid (RSOH), while RSCl was found to be the intermediate in reactions with HOCl.
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