AI Article Synopsis
- Biosimilars, including infliximab and adalimumab versions, offer cost savings and increased access to effective monoclonal antibodies (mAbs) for patients, particularly those with conditions like inflammatory bowel disease (IBD).
- Several adalimumab biosimilars (ABP501, BI 695501, GP2017, SB5) have been approved and show high similarity to the original product, Humira®, with clinical data supporting their efficacy and safety in rheumatoid arthritis and psoriasis.
- However, the lack of data for IBD patients poses a challenge, and future decisions will focus on selecting the right patients for biosimilars, potentially switching them between different options, and evaluating overall treatment strategies.
Article Abstract
: Biosimilars represent great potential in cost saving and re-investment opportunities in healthcare and allow patients greater access to effective mAbs. Infliximab biosimilars are successfully used in all indications for whom the reference product (RP) was approved. : In late 2018, adalimumab biosimilars will also be available in patients with inflammatory bowel disease (IBD). ABP501, BI 695501, GP2017, and SB5 have been approved by the EMA for the same indications of the reference product (RP, Humira®). Preclinical data show high similarity between all biosimilars and the RP. Clinical data in patients with rheumatoid arthritis and psoriasis also show no differences in terms of efficacy, safety, and immunogenicity. Data in IBD patients are still lacking. : Biosimilars of adalimumab appear to be clinically equivalent to the RP. Decisions based on choosing the ideal patient to receive or to be switched to a biosimilar of adalimumab, or choosing one biosimilar vs. another, or cross-switching among biosimilars remain the next challenge in the field of IBD.
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| http://dx.doi.org/10.1080/14712598.2019.1564033 | DOI Listing |
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