AI Article Synopsis
- The aqueous and ethanolic extracts of Lippia sidoides were analyzed for their effects on enzymes related to inflammation, blood coagulation, and digestion.
- Both extracts were found to enhance certain enzyme activities in snake venom and showed varying degrees of inhibition on hemolysis and thrombolysis caused by different snake venoms.
- The extracts also exhibited the ability to reduce digestive enzyme activities, particularly α-glycosidases and lipases, and their rich phenolic content suggests potential for health benefits or nutraceutical applications.
Article Abstract
The aqueous and ethanolic extracts of Lippia sidoides Cham. were chemically characterized and tested for their action on enzymes involved in processes such as inflammation, blood coagulation, and digestion. Both extracts potentiated the activity of phospholipases A present in the venom of Bothrops atrox in 12 % and completely inhibited the hemolysis induced by B. jararacussu and B. moojeni venoms in the proportions between 1 : 0.5 and 1 : 5 (venom/extracts (w/w)). They inhibited the thrombolysis induced by B. moojeni (10 to 25 %), potentiated the thrombolysis induced by the Lachesis muta muta venom (30 to 80 %), prolonged the coagulation time induced by B. moojeni and L. muta muta venoms, and presented antigenotoxic action. Both extracts reduced the activity of α-glycosidases, the aqueous extract inhibited lipases, and the ethanolic extract inhibited α-amylases. The results demonstrate the modulatory action of the extracts on proteases, phospholipases, and digestive enzymes. In addition, the rich phenolic composition of these extracts highlights their potential for nutraceutical use.
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| http://dx.doi.org/10.1002/cbdv.201800558 | DOI Listing |
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