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Primary Sclerosing Cholangitis Associated With Ulcerative Colitis Coexisting With Cholangiocarcinoma: A Case Report.
Cureus
June 2024
Medicine, University Medical Center, Taibah University, Al-Madinah al-Munawwarah, SAU.
Primary sclerosing cholangitis (PSC) is a rare chronic inflammatory disease in which multifocal fibrosis of bile ducts causes eventually narrowing and even blocking, forming multifocal strictures alternated to dilatations. Here, we reported an extremely rare case of PSC associated with ulcerative colitis (UC) and coexisting with cholangiocarcinoma in a 33-year-old male presented with right upper quadrant pain and dark urine. Liver function tests were deranged, and ERCP found a beaded cholangiography appearance due to multifocal bile duct strictures alternating with normal and dilated segments of the common hepatic duct and the intrahepatic bile ducts.
View Article and Find Full Text PDFAn atypical case of isolated immunoglobulin G4-related sclerosing cholangitis with a cholangiogram resembling primary sclerosing cholangitis.
Clin J Gastroenterol
April 2024
Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, 65, Tsuruma-Cho, Showa-Ku, Nagoya, 466-8560, Japan.
An asymptomatic 77-year-old man with intrahepatic bile duct dilation was referred to our hospital. Cholangiography revealed alternations between strictures and dilated segments from the right and left hepatic ducts to the lower bile ducts, with findings of a pruned tree, beaded, shaggy appearance, and diverticulum-like outpouching. Histopathology revealed abundant immunoglobulin G4 (IgG4)-positive plasma cells (> 10 per high-power field) with an IgG4/IgG-positive cell ratio of 40-50%.
View Article and Find Full Text PDFA case of atypical IgG4-related disease presenting hypereosinophilia, polyneuropathy, and liver dysfunction.
Mod Rheumatol Case Rep
December 2023
Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Article Synopsis
- IgG4-related disease (Ig4-RD) is a condition that can impact various organs, such as the salivary and lacrimal glands, pancreas, and liver.
- A 72-year-old woman exhibited multiple symptoms including high eosinophil counts, elevated IgG4 levels, and dysfunction in liver and nerves, which led to a diagnosis of Ig4-RD confirmed through biopsies.
- The patient showed improvement with glucocorticoid treatment, emphasizing the importance of biopsies to correctly differentiate Ig4-RD from similar disorders.
Primary Sclerosing Cholangitis- A Rare Cause of Obstructive Jaundice: A Case Report.
Mymensingh Med J
January 2023
Professor Dr Md Mohsen Chowdhury, Professor and Chairman, Hepatobiliary, Pancreatic & Liver transplant Surgery Department, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh; E-mail:
Diagnosis of primary sclerosing cholangitis (PSC) is often very difficult and may have a suspicion with altered liver functions. PSC is known to be associated with inflammatory bowel disease. This article presents a case study of a 70 years old male patient who presented with obstructive jaundice with recurrent episode of cholangitis in June 2019 at Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh.
View Article and Find Full Text PDFCOVID-19-associated secondary sclerosing cholangitis - A case series of 4 patients.
Clin Res Hepatol Gastroenterol
December 2022
Gastroenterology department, Hospital Professor Doutor Fernando Fonseca, IC 19, 2720-276 Amadora, Portugal.
We report a case series of four patients diagnosed with COVID-19-associated secondary sclerosing cholangitis (SSC), a recently described rare late complication of severe COVID-19. Following prolonged stays in the intensive care unit, these patients developed marked sustained cholestasis and jaundice despite clinical improvement. Cholangiography showed beaded appearance of intra-hepatic bile ducts and bile casts were removed in one patient.
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