Clozapine is an antipsychotic known for its superior efficacy in treating drug-resistant Schizophrenia. However, Clozapine induces various side effects such as hyperglycemia, agranulocytosis, weight gain etc. The mechanisms of these Clozapine-induced side effects have remained largely elusive though an important role is ascribed to 5-HT (Serotonin receptor subtype-2A). In this pilot study, we report for the first time that the 5-HT 'global' knockout mice (Htr2a) are resistant to the Clozapine-induced hyperglycemia. Importantly though, the Htr2a mice exhibit near normal basal glucose metabolism in the glucose tolerance tests. Collectively, the Htr2a mice provide an important tool to study the Clozapine-induced hyperglycemia.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jphs.2018.11.015 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Clozapine impaired glucose-stimulated insulin secretion partly by increasing plasma 5-HT levels due to the inhibition of OCT1-mediated hepatic 5-HT uptake in mice.
Acta Pharmacol Sin
October 2024
Center of Drug Metabolism and Pharmacokinetics, School of Pharmacy, China Pharmaceutical University, Nanjing, 210029, China.
Patients taking atypical antipsychotics (AAPs), especially clozapine, are often associated with hyperglycaemia. Here, clozapine served as a representative agent for investigating how AAPs induce hyperglycaemia. In normal mice and mice fed a high fat diet (HFD), clozapine impaired glucose tolerance and glucose-stimulated insulin secretion (GSIS) following intraperitoneal glucose administration and increased plasma 5-HT levels.
View Article and Find Full Text PDFArticle Synopsis
- Clozapine, a medication for schizophrenia, can cause diabetes, but there is little research on its effects on glucose levels in patients.
- A case is reported where a patient experienced repeated reactive hypoglycemia linked to abnormal glucose tolerance while on clozapine.
- Regular monitoring of glucose levels is crucial during clozapine treatment to prevent complications and potential discontinuation of the medication.
[Basic and Clinical Research Based on Clinical Questions:Reduction of Antipsychotic Medication-induced Adverse Events].
Yakugaku Zasshi
October 2023
Department of Psychiatry, Hokkaido University Hospital.
Antipsychotics are widely used to manage mental illnesses. They have, however, been reported to cause various adverse events. Two studies were conducted to resolve clinical questions related to adverse events caused by antipsychotic medications in clinical practice.
View Article and Find Full Text PDFRapid-onset clozapine-induced hyperglycaemia: pathways of glycaemic dysregulation.
BMJ Case Rep
September 2021
Endocrinology Department, Braga Hospital, Braga, Portugal.
Clozapine is an atypical antipsychotic used in refractory schizophrenia, also efficient in alleviating dyskinesia in Parkinson's disease. Despite its potency, this drug is associated with severe metabolic side effects, including increased risk for diabetes. We report the case of a 45-year-old overweight woman with Parkinson's disease who presented with rapid-onset hyperglycaemia within 2 months after starting clozapine for refractory dyskinaesia.
View Article and Find Full Text PDFEffect of liraglutide on neural and peripheral markers of metabolic function during antipsychotic treatment in rats.
J Psychopharmacol
March 2021
School of Medicine, Faculty of Science, Medicine and Health, University of Wollongong, Wollongong, Australia.
Background: Liraglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist that prevents metabolic side effects of the antipsychotic drugs (APDs) olanzapine and clozapine through unknown mechanisms.
Aim: This study aimed to investigate the effect of chronic APD and liraglutide co-treatment on key neural and peripheral metabolic signals, and acute liraglutide co-treatment on clozapine-induced hyperglycaemia.
Methods: In study 1, rats were administered olanzapine (2 mg/kg), clozapine (12 mg/kg), liraglutide (0.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!