Surface nuclear magnetic resonance (SNMR) technology is widely used in the detection of groundwater due to its non-invasive, qualitative, and quantitative advantages. Nonetheless, SNMR is difficult to employ in a high ambient noise level because of the weak level of nanovolt signals (10 V). To solve this problem, pre-polarization (PP) technology is utilized for SNMR detection. That is, the combination of direct current, i.e., PP pulse, with alternating current (AC) pulses is utilized to increase the signal amplitude of shallow hydrogen protons. However, the PP and AC pulses on the same transmitting coil should be output independently when using the PP SNMR system. Meanwhile, to avoid magnetization loss, the process of shutting down the PP field must be both rapid and adiabatic. To solve the above problems, we improved the transmitting part of the PP SNMR system and designed a discharge circuit for PP pulses. The feasibility of the design was demonstrated through both software simulation and actual testing. When the PP current is 91 A, it can be turned off within 3 ms. Via further water measurements in an electromagnetically shielded room, we demonstrated that a PP system with a PP pulse discharge circuit can effectively increase the initial amplitude of the signal.
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http://dx.doi.org/10.1063/1.5048552 | DOI Listing |
Sci Rep
December 2024
Center of Excellence in Catalysis and Catalytic Reaction Engineering, Department of Chemical Engineering, Faculty of Engineering, Chulalongkorn University, Bangkok, 10330, Thailand.
Glycerol, a by-product of biodiesel production, could be converted into various value-added products. This work focuses on its dehydrogenation to dihydroxyacetone (DHA), which is mainly used in the cosmetics industry. While several methods have been employed for DHA production, some necessitate catalysts and involve harsh reaction conditions as well as long reaction times.
View Article and Find Full Text PDFBMC Ophthalmol
December 2024
School of Medicine, Xiamen Eye Center and Eye Institute of Xiamen University, Xiamen, 361000, China.
Purepose: The intraoperative femtosecond laser time, Cumulative Dissipated Energy (CDE), Effective Phacoemulsification time (EPT), and intraoperative fluid perfusion volume were compared under different model fragmentation modes using Catalys femtosecond laser system.
Methods: This was a single-center, prospective, randomized controlled study. A total of 120 eyes who underwent femtosecond laser-assisted cataract phacoemulsification combined with intraocular lens implantation in Xiamen Eye Center affiliated to Xiamen University from September 2022 to March 2023 were randomly divided into 4 groups to undergo pre-nucleus splitting in different ways: Group 1: six-split, Group 2: eight-split, Group 3: six-split + gridded softening, and Group 4: eight-split + gridded softening.
Sci Rep
December 2024
School of Physics Science and Engineering, Tongji University, Shanghai, 200092, People's Republic of China.
In this study, we investigate the application of support vector machines utilizing a radial basis function kernel for predicting nuclear α-decay half-lives. Our approach integrates a comprehensive set of physics-derived features, including characteristics derived from nuclear structure, to systematically evaluate their impact on predictive accuracy. In addition to traditional parameters such as proton and neutron numbers, as well as terms based on the liquid drop model (e.
View Article and Find Full Text PDFDev Cell
December 2024
Institut Curie, CNRS UMR 144, PSL University, 75005 Paris, France. Electronic address:
The phosphatidylinositol 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway is frequently hyperactivated in triple-negative breast cancers (TNBCs) associated with poor prognosis and is a therapeutic target in breast cancer management. Here, we describe the effects of repression of mTOR-containing complex 1 (mTORC1) through knockdown of several key mTORC1 components or with mTOR inhibitors used in cancer therapy. mTORC1 repression results in an ∼10-fold increase in extracellular matrix proteolytic degradation.
View Article and Find Full Text PDFJ Colloid Interface Sci
December 2024
School of Health Sciences, Stopford Building, The University of Manchester, Oxford Road, Manchester M13 9PT, UK.
Hypothesis: Nanoscale characterisation of the self-associated species formed by amphiphilic pharmaceuticals in aqueous solution carries relevance across their entire journey from development through to manufacture - relevant, therefore, not only as regards formulation of the drug products as medicines, but also potentially relevant to their bioavailability, activity, and clinical side effects. Such knowledge and understanding, however, can only be fully secured by applying a range of experimental and theoretical methodologies.
Experiments: Herein, we apply a synergistic combination of solubility, surface tension, SANS, NMR and UV spectroscopic studies, together with MD simulation and QM calculations, to investigate the meso-structures of propranolol hydrochloride aggregates in bulk aqueous solutions, at concentrations spanning 2.
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