A common approach for spectrum determination of polyenergetic proton bunches from laser-ion acceleration experiments is based on the time-of-flight (TOF) method. However, spectra obtained using this method are typically given in relative units or are estimated based on some prior assumptions on the energy distribution of the accelerated ions. In this work, we present a new approach using the TOF method that allows for an absolute energy spectrum reconstruction from a current signal acquired with a sub-nanosecond fast and 10 m thin silicon detector. The reconstruction is based on solving a linear least-squares problem, taking into account the response function of the detection system. The general principle of signal generation and spectrum reconstruction by setting up an appropriate system response matrix is presented. Proof-of-principle experiments at a 12 MV Tandem accelerator using different nanosecond-short (quasi-)monoenergetic and polyenergetic proton bunches at energies up to 20 MeV were successfully performed. Within the experimental uncertainties of 2.4% and 12.1% for energy and particle number, respectively, reconstructed energy distributions were found in excellent agreement with the spectra calculated using Monte Carlo simulations and measured by a magnetic spectrometer. This TOF method can hence be used for absolute online spectrometry of laser-accelerated particle bunches.
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http://dx.doi.org/10.1063/1.5052059 | DOI Listing |
Med Phys
May 2022
Department of Medical Physics, Wuhan University, Wuhan, China.
Purpose: Online dose verification based on proton-induced positron emitters requires high accuracy in the assignment of elemental composition (e.g., C and O).
View Article and Find Full Text PDFPhys Med Biol
July 2021
University of Oxford, Department of Oncology, Oxford, United Kingdom.
To develop a framework to include oxygenation effects in radiation therapy treatment planning which is valid for all modalities, energy spectra and oxygen levels. The framework is based on predicting the difference in DNA-damage resulting from ionising radiation at variable oxygenation levels.Oxygen fixation is treated as a statistical process in a simplified model of complex and simple damage.
View Article and Find Full Text PDFZ Med Phys
February 2022
Department of Medical Physics, Faculty of Physics, Ludwig-Maximilians-Universität München, Germany.
Laser-accelerated proton bunches with kinetic energies up to several tens of MeV and at repetition rates in the order of Hz are nowadays achievable at several research centres housing high-power laser system. The unique features of such ultra-short bunches are also arousing interest in the field of radiological and biomedical applications. For many of these applications, accurate positioning of the biological target is crucial, raising the need for on-site imaging.
View Article and Find Full Text PDFPhys Med Biol
April 2020
Department of Radiation Oncology, Hospital of The University of Pennsylvania, Philadelphia, PA, United States of America. Department of Atomic, Molecular and Nuclear Physics, Universidad de Sevilla, Seville, Spain.
To calculate 3D distributions of microdosimetric-based restricted dose-averaged LET (LETd) and dose-mean lineal energy ([Formula: see text]) in order to explore their similarities and differences between each other and with the traditional unrestricted LETd. Additionally, a new expression for optimum restricted LETd calculation is derived, allowing for disregarding straggling-associated functions in the classical microdosimetric theory. Restricted LETd and [Formula: see text] for polyenergetic beams can be obtained by integrating previously developed energy-dependent microdosimetric functions over the energetic spectrum of these beams.
View Article and Find Full Text PDFPhys Med Biol
November 2019
Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, United States of America. Author to whom any correspondence should be addressed.
The purpose of this study was to generate physical data needed for microdosimetry-based models of proton RBE. Our focus was on the frequency and dose average lineal energies, y and y . We report data for proton energies from 0.
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