Background: Obsessive-compulsive disorder (OCD) is characterized by persistent, intrusive, and distressing obsessions and/or compulsions and is associated with marked impairments in quality of life. The goal of the present study was to examine initial stages of information processing, specifically, perceptual and attention orientation phases that precede response preparation in OCD.
Methods: The P3 event-related potential (ERP) component was used as a measure of early cognitive processes of visual stimulus perception. ERPs were recorded while 38 participants diagnosed with OCD and 38 healthy controls performed a passive visual oddball task with neutral and angry schematic faces.
Results: OCD participants demonstrated significantly enhanced P3 amplitude over bilateral parietal areas in response to neutral stimuli that activate basic primary perceptual processes. Emotional valence reduced this effect such that OCD patients did not differ from healthy controls in P3 amplitude under the angry stimuli condition.
Limitations: Patients in this study were noncomorbid and unmedicated partially limiting the generalizability of the results.
Conclusions: Our hypothesis of altered early perceptual processes in OCD was supported. These alterations, specific to OCD and not anxiety and depression symptoms, may represent distracted primary cognitive processes in OCD, possibly serving as a basic source for compulsion initiation.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jad.2018.12.109 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The effects of aerobic exercise on goal-directed attention and inhibitory control in individuals with high trait anxiety: an EEG study.
BMC Psychol
January 2025
Faculty of Psychology, Naval Medical University, Shanghai, China.
Anxiety is known to significantly impair cognitive function, particularly attentional control. While exercise has been demonstrated to alleviate these cognitive deficits, the precise neural mechanisms underlying these effects remain poorly understood. This study examines the effects of exercise on attentional control in individuals with high trait anxiety, based on attentional control theory, which suggests that such individuals have reduced top-down attention.
View Article and Find Full Text PDFEvaluating cognitive bias in clinical ethics supports: a scoping review.
BMC Med Ethics
January 2025
Unité de Neurophysiologie du Stress, Institut de Recherche Biomédicale Des Armées, Brétigny Sur Orge Cedex, 91223, France.
Background: A variety of cognitive biases are known to compromise ethical deliberation and decision-making processes. However, little is known about their role in clinical ethics supports (CES).
Methods: We searched five electronic databases (Pubmed, PsychINFO, the Web of Science, CINAHL, and Medline) to identify articles describing cognitive bias in the context of committees that deliberate on ethical issues concerning patients, at all levels of care.
Indoor ventilation frequency and cognitive function among Chinese old adults: the multiple mediation effect of anxiety and self-rated health.
BMC Geriatr
January 2025
Nursing School, Medical College of Hengyang, University of South China, Hengyang, China.
Background: China is experiencing an increasingly serious aging population. Cognitive function is an important factor and guarantee for the quality of life of older people. Therefore, to achieve healthy aging, this study aimed to examine the sequential multiple mediating effects of indoor ventilation frequency and cognitive function on anxiety and self-rated health in the Chinese older people population.
View Article and Find Full Text PDFError-driven upregulation of memory representations.
Commun Psychol
January 2025
Institute of Psychology, Otto-von-Guericke-University Magdeburg, Magdeburg, Germany.
Learning an association does not always succeed on the first attempt. Previous studies associated increased error signals in posterior medial frontal cortex with improved memory formation. However, the neurophysiological mechanisms that facilitate post-error learning remain poorly understood.
View Article and Find Full Text PDFAlzheimer's disease may develop from changes in the immune system, cell cycle, and protein processing following alterations in ribosome function.
Sci Rep
January 2025
Medical Genome Center, Research Institute, National Center for Geriatrics and Gerontology, 7-430 Morioka-cho, Obu, 474-8511, Aichi, Japan.
The prevalence of Alzheimer's disease (AD) is increasing as society ages. The details of AD pathogenesis have not been fully elucidated, and a comprehensive gene expression analysis of the process leading up to the onset of AD would be helpful for understanding the mechanism. We performed an RNA sequencing analysis on a cohort of 1227 Japanese blood samples, representing 424 AD patients, 543 individuals with mild cognitive impairment (MCI), and 260 cognitively normal (CN) individuals.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!