Plaque formation due to amyloid-β oligomerization and fibrillation is a key issue for its deposition in the brains of dementia and Alzheimer's disease patients. Related drugs preventing this peptide fibril accumulation bear the potential of considerable medical and social value. In this study, we performed fibrillation inhibition tests with eight different medical plant extracts and nutraceuticals using fluorescence spectroscopy. Successful inhibition of the following plant extracts and nutraceuticals were obtained: , , and , providing new drug candidates for the prevention and treatment of Alzheimer's disease.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311354 | PMC |
| http://dx.doi.org/10.3233/ADR-180066 | DOI Listing |
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