AI Article Synopsis
- Pemphigus vulgaris (PV) is an autoimmune disease leading to severe skin and mucous membrane blisters due to the body mistakenly targeting its own cells.
- The disease mechanism involves antibodies binding to desmoglein 3, a protein crucial for cell adhesion.
- Treatment primarily involves corticosteroids, and the article includes case studies discussing diagnosis, treatment, and patient outcomes.
Article Abstract
Pemphigus vulgaris (PV) is an autoimmune, potentially life-threatening disease causing blisters and erosions of the skin and mucous membranes associated with intraepithelial acantholysis. The underlying mechanism responsible for causing intraepithelial lesions is the binding of immunoglobulin G autoantibodies to desmoglein 3, a transmembrane glycoprotein adhesion molecule present on desmosomes. Histological features comprise intraepithelial cleft and Tzanck cells. Corticosteroids remain the mainstay of the treatment plan. In this article, we have discussed about the diagnosis of three patients suffering from PV, the treatment rendered, and the outcome of the same.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259552 | PMC |
| http://dx.doi.org/10.4103/jfmpc.jfmpc_133_18 | DOI Listing |
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