AI Article Synopsis
- - A 54-year-old man experienced mania as a side effect of the medication dapsone, although the exact mechanism for this reaction is still unclear.
- - The study found a direct correlation between the severity of the man's manic symptoms and his levels of methemoglobinemia, a condition where hemoglobin cannot effectively release oxygen to the body.
- - This case suggests that dapsone-induced mania may be tied to methemoglobinemia levels, proposing a new hypothesis on how dapsone may trigger manic episodes.
Article Abstract
Background: The underlying mechanism involved in dapsone-induced mania remains unknown.
Methods: We report the case of a 54-year-old man with a dapsone-induced mania.
Results: The maximum of manic symptoms was correlated with the maximum of methemoglobinemia and mania decreased concomitantly with the methemoglobinemia level.
Limitations: This is a single case.
Conclusions: This case shows that dapsone-induced mania severity is correlated with methemoglobinemia level, leading for the first time to the hypothesis of a physiopathological mechanism by which dapsone could induce mania.
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| http://dx.doi.org/10.1016/j.jad.2018.12.123 | DOI Listing |
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Methemoglobinemia as a biomarker of dapsone-induced mania severity.
J Affect Disord
July 2019
Service Hospitalo-Universitaire de Psychiatrie de Bicêtre, Hôpitaux Universitaires Paris-Sud, Assistance Publique-Hôpitaux de Paris, Hôpital de Bicêtre, Le Kremlin Bicêtre, F-94275, France; INSERM UMR-1178, CESP, "Depression and Antidepressants" team, Faculté de Médecine Paris-Sud, Université Paris Sud, France.
Background: The underlying mechanism involved in dapsone-induced mania remains unknown.
Methods: We report the case of a 54-year-old man with a dapsone-induced mania.
Results: The maximum of manic symptoms was correlated with the maximum of methemoglobinemia and mania decreased concomitantly with the methemoglobinemia level.
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