AI Article Synopsis
- * A study analyzed the immune response in broiler chickens after infection, measuring antibodies and gene expression levels of key immune markers (IFNγ, IL-12, IL-18) at various time points post-infection.
- * Results showed that infected chickens had higher levels of specific antibodies and significant increases in immune gene expression compared to uninfected controls, providing insights for better vaccine development.
Article Abstract
Salmonella enterica serovar Typhimurium (S. Typhimurium) is a primary avian pathogen responsible for severe intestinal pathology in younger chickens and economic losses to poultry industry. Furthermore, S. Typhimurium is also able to cause infection in humans, characterized by acute gastrointestinal disease. A study was conducted to investigate antibody response and expression kinetics of interferon gamma (IFNγ), interleukin (IL-12, and IL-18) genes in broiler chicken at 0, 1, 3, 5, 7, 9, 11, 13, and 15 D post infection following experimental infection of S. Typhimurium. Immunological studies showed higher titres of IgG and IgM in the infected group as compared to the age-matched un-infected control group. The Real-Time PCR-based gene expression analysis revealed significant increase of IFNγ, IL-12, and IL-18 mRNA levels in the infected group as compared to their respective controls (P < 0.05). The present study shall help in understanding the immune responses in birds, thus allowing development of more effective vaccines and vaccination strategies.
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| http://dx.doi.org/10.3382/ps/pey560 | DOI Listing |
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