Electrophilic N-F fluorination agents underpin the introduction of fluorine in aliphatic systems across drug and academic research. The choice of N-F reagent is currently determined through empirical experimentation in the absence of quantitative values for electrophilicities. Here we report an experimentally-determined kinetic reactivity scale for ten N-F fluorinating reagents, including Selectfluor™, NFSI, Synfluor™ and several -fluoropyridinium salts, in CHCN. The reactivity scale, which covers eight orders of magnitude, employs -substituted 1,3-diaryl-1,3-dicarbonyl derivatives to measure relative and absolute rate constants. The -substituted 1,3-diaryl-1,3-dicarbonyl scaffold delivers a convenient, sensitive spectrophotometric reporter of reactivity that also led to the discovery of a unique form of tautomeric polymorphism.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6263395 | PMC |
| http://dx.doi.org/10.1039/c8sc03596b | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Ultrasound-guided femoral nerve block reduced the incidence of postoperative delirium after total knee arthroplasty: A double-blind, randomized study.
Medicine (Baltimore)
November 2024
Department of Anesthesiology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
Background: Postoperative delirium (POD) is an acute brain dysfunction that mainly occurs in elderly patients after surgery. Postoperative pain is an important factor in the occurrence of POD, and effective pain management can reduce the risk of POD. Our study aims is to investigate the effect of ultrasound-guided femoral nerve block (FNB) on postoperative pain and the occurrence of POD after knee arthroplasty, and whether its mechanism is related to oxidative stress, inflammatory factors.
View Article and Find Full Text PDFLong-lasting and controlled-release borate as a biocide against microbial breeding in a recirculating cooling water system.
Sci Total Environ
January 2025
State Key Laboratory of Water Environment Simulation, School of Environment, Beijing Normal University, Beijing 100875, China; The Key Laboratory of Water and Sediment Sciences, Ministry of Education, School of Environment, Beijing Normal University, Beijing 100875, China.
Based on the potential bactericidal properties of borate, we synthesized controlled-release borate (CRB) as a novel biocide to inhibit microbial proliferation in a recirculating cooling water system (RCS). In this study, toxicity experiments of CRB were conducted on the dominant bacteria and algae isolated from an actual RCS. The effects of CRB on biocidal performance and genotoxicity were evaluated in a simulated RCS.
View Article and Find Full Text PDFEfficacy of probiotic adjuvant therapy in women with major depressive disorder: insights from a case series study.
Pharmacol Rep
January 2025
Laboratory of Translational Physiology and Pharmacology, Pharmaceutical Sciences Graduate Program, Vila Velha University (UVV), R Mercurio s/n, Vila Velha, ES, 29102623, Brazil.
Background: The therapeutic targeting of the intestinal microbiota has gained increasing attention as a promising avenue for addressing mood disorders. This study aimed to assess the potential effect of supplementing standard pharmacological treatment with the probiotic kefir in patients with Major Depressive Disorder (MDD).
Methods: Thirty-eight female participants diagnosed with moderate MDD by the Hamilton Rating Scale for Depression (HAM-D) were selected to receive the probiotic kefir in conjunction with antidepressant therapy for 12 weeks.
Can Peer Acceptance and Perceptual Accuracy Impact the Effectiveness of Two Formats of a Preventative Intervention on Functional Subtypes of Aggression in Youth?
Prev Sci
January 2025
Center for Youth Development & Intervention, The University of Alabama, Tuscaloosa, AL, 35487, USA.
Coping Power (CP) is an empirically supported school-based intervention for children at risk for aggression. A child's social status with peers and the extent to which they accurately perceive it are important aspects of preadolescent social development that may influence how intervention format affects disruptive behavior outcomes. Further, reactive (RA) and proactive (PA) functional subtypes of aggression have differential relations with peer acceptance.
View Article and Find Full Text PDFA broad spectrum Shigella vaccine based on VirG multiepitope region produced in a cell-free system.
NPJ Vaccines
January 2025
Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD, USA.
Dysentery caused by Shigella species remains a major health threat to children in low- and middle-income countries. There is no vaccine available. The most advanced candidates, i.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!