This work proposes an approach for Cu sensing in water which combines the selectivity of the Gly-Gly-His (GGH) peptide probe with the sensitivity of the electrolyte-gated organic field-effect transistor (EGOFET). The oligopeptide probe was immobilized onto the gate electrode of the transistor by electrooxidation of the primary amine of the glycine moiety. Cu complexation by the grafted GGH was at first electrochemically evidenced, using cyclic and square wave voltammetries, then it was demonstrated that GGH-functionalized EGOFETs can transduce Cu complexation through a significant threshold voltage shift and therefore a change in drain current. The limit of detection is ca. 10 M and the sensitivity in the linear range (10 - 10 M) is 1 mA dec (drain current variations).
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