AI Article Synopsis
- This study explores the use of folic acid and BSA (bovine serum albumin) coated gold nanoclusters (FA-AuNCs) to improve the effectiveness of radiation therapy on intracranial C6 glioma tumors.
- Results show that C6 cancer cells absorb about 2.5 times more FA-AuNCs compared to normal cells, leading to a higher concentration of these nanoclusters in brain tumors than in surrounding healthy tissue.
- Additionally, treatment with FA-AuNCs combined with radiation therapy nearly doubled the survival time of glioma-bearing rats and significantly reduced tumor cell growth, indicating their potential as effective radiosensitizers.
Article Abstract
The aim of the present study is to investigate folic acid and BSA decorated gold nanoclusters (FA-AuNCs) effect on the enhancement of intracranial C6 glioma tumors radiation therapy (RT) efficacy. Inductively coupled plasma optical emission spectrometry (ICP-OES) measurements exhibited about 2.5 times more FA-AuNCs uptake by C6 cancer cells (32.8 ng/10 cells) than the normal cells. FA-AuNCs had significantly higher concentration in the brain tumors (8.1 μg/mg) in comparison with surrounding normal brain tissue (4.3 μg/mg). Moreover, FA-AuNCs exhibited dose enhancement factor (DEF) of 1.6. The glioma-bearing rats' survival times were almost doubled at radiation therapy + FA-AuNCs (25.0 ± 1.5 days) in comparison with no-treatment group (12.8 ± 0.7 days). The Ki-67 labeling index was 48.89% ± 9.93 for control, 29.98% ± 8.32 for RT, and 11.53% ± 7.65 for RT + FA-AuNCs. Therefore, FA-AuNCs can be effective radiosensitizers for intracranial glioma tumors RT.
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| http://dx.doi.org/10.1016/j.nano.2018.12.007 | DOI Listing |
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