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Increased NOX-dependent ROS production and proportionally enhanced antioxidant response in white adipose tissue of male rats.
Arch Endocrinol Metab
January 2025
Universidade Estadual do Ceará Instituto Superior de Ciências Biomédicas Laboratório de Fisiologia Endócrina e Metabolismo FortalezaCE Brasil Laboratório de Fisiologia Endócrina e Metabolismo, Instituto Superior de Ciências Biomédicas, Universidade Estadual do Ceará, Fortaleza, CE, Brasil.
Objective: This study aimed to investigate the redox balance in subcutaneous and retroperitoneal fat pads of male and female Wistar rats.
Materials And Methods: The study analyzed the activity and gene expression of the antioxidant enzymes superoxide dismutase, catalase, and glutathione peroxidase, along with the production of NADPH oxidases dependent on HO and gene expression of NOX1, NOX2, and NOX4.
Results: The retroperitoneal fat pad in males compared with females had greater NOX2 and NOX4 expression, along with higher superoxide dismutase activity.
Iron-associated lipid peroxidation in Alzheimer's disease is increased in lipid rafts with decreased ferroptosis suppressors, tested by chelation in mice.
Alzheimers Dement
January 2025
Leonard Davis School of Gerontology, University of Southern California, Los Angeles, California, USA.
Introduction: Iron-mediated cell death (ferroptosis) is a proposed mechanism of Alzheimer's disease (AD) pathology. While iron is essential for basic biological functions, its reactivity generates oxidants which contribute to cell damage and death.
Methods: To further resolve mechanisms of iron-mediated toxicity in AD, we analyzed post mortem human brain and ApoEFAD mice.
Short-term airborne ultrasound induced cell death in tobacco cells and changed their wall components.
Sci Rep
January 2025
Department of Physics, Faculty of Basic Sciences, Shahed University, Tehran, Iran.
The effects of low-intensity ultrasound on plants such as piezoelectric and ultrasonic water baths, on plants have been extensively studied. However, the specific effect of airborne ultrasound on plant cells has yet to be reported. The present study was conducted to elucidate the physiological responses of plant cells to airborne US.
View Article and Find Full Text PDFConvergent evolution of oxidized sugar metabolism in commensal and pathogenic microbes in the inflamed gut.
Nat Commun
January 2025
Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, College Park, MD, USA.
Inflammation-associated perturbations of the gut microbiome are well characterized, but poorly understood. Here, we demonstrate that disparate taxa recapitulate the metabolism of the oxidized sugars glucarate and galactarate, utilizing enzymatically divergent, yet functionally equivalent, gud/gar pathways. The divergent pathway in commensals includes a putative 5-KDG aldolase (GudL) and an uncharacterized ABC transporter (GarABC) that recapitulate the function of their non-homologous counterparts in pathogens.
View Article and Find Full Text PDFTFEB-dependent autophagy-lysosomal pathway is required for NRF2-driven antioxidative action in obstructive sleep apnea-induced neuronal injury.
Cell Signal
January 2025
Respiratory Department, Tianjin Medical University General Hospital, Tianjin Medical University, 300052 Tianjin, China. Electronic address:
Nearly one billion individuals worldwide suffer from obstructive sleep apnea (OSA) and are potentially impacted by related neurodegeneration. TFEB is considered a master regulator of autophagy and lysosomal biogenesis, but little is known about its role in neuronal oxidative stress and resultant injury induced by OSA. This study aimed to investigate these issues.
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