AI Article Synopsis
- Despite advancements in hepatitis C virus (HCV) research, a successful vaccine has not been developed, mainly due to the high costs of treatments and increasing infections linked to opioid abuse.
- Humanized mice, including liver chimeras and genetically modified models, serve as crucial tools for testing potential vaccines and antibody therapies.
- This chapter explores various methods using humanized mouse technology to enhance our understanding of preventing HCV infection.
Article Abstract
In spite of the immense progress in hepatitis C virus (HCV) research, efforts to prevent infection, such as generating a vaccine, have not yet been successful. The high price tag associated with current treatment options for chronic infection and the spike in new infections concurrent with growing opioid abuse are strong motivators for developing effective immunization and understanding neutralizing antibodies' role in preventing infection. Humanized mice-both human liver chimeras as well as genetically humanized models-are important platforms for testing both possible vaccine candidates as well as antibody-based therapies. This chapter details the variety of ways humanized mouse technology can be employed in pursuit of learning how HCV infection can be prevented.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6699619 | PMC |
| http://dx.doi.org/10.1007/978-1-4939-8976-8_33 | DOI Listing |
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