AI Article Synopsis
- Delirium is a prevalent issue in adult cardiac surgery patients, significantly increasing the risks of morbidity and mortality.
- A systematic review and network meta-analysis will assess which pharmacologic interventions are most effective in preventing delirium, analyzing data from multiple medical databases.
- The study aims to provide compelling evidence on the efficacy and safety of various treatments, with results expected to be published in a peer-reviewed journal.
Article Abstract
Background: Delirium is common in adult patients undergoing cardiac surgery and related to a high morbidity and mortality. Although a variety of pharmacologic interventions have been applied in delirium prevention, there is still uncertainty concerning which drug is optimal. Thus, we plan to conduct a systematic review and network meta-analysis (NMA) of published studies to assess the efficacy and safety of pharmacologic interventions for preventing delirium among those patients.
Methods: A systematic literature search will be conducted in Embase, PubMed, and the Cochrane Library. The primary outcome will be the incidence of postoperative delirium. Secondary outcomes will include all-cause mortality and length of hospital or intensive care unit stay. A frequentist NMA will be conducted using Stata version 14.0. The inconsistency between direct and indirect comparisons will be evaluated using a node splitting method. In addition, surface under the cumulative ranking area will be used to evaluate superiority of different treatments.
Results: The findings of our review will be submitted to a peer-reviewed publication.
Conclusion: Our study will generate convincing evidence regarding the effectiveness and safety of different pharmacologic interventions for delirium prevention in cardiac surgery patients.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314755 | PMC |
| http://dx.doi.org/10.1097/MD.0000000000013881 | DOI Listing |
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