AI Article Synopsis
- The study aimed to examine how overexpressing the LATS2 gene affects the growth and programmed cell death (apoptosis) of oral squamous cell carcinoma (OSCC) cells.
- Researchers used lentiviral particles to increase LATS2 levels in SCC-25 cells and measured changes in cell growth and apoptosis through various assays.
- Results showed that higher LATS2 expression slowed down SCC-25 cell growth and led to increased apoptosis by altering the levels of key proteins involved in cell survival.
Article Abstract
Objective: To investigate the effect of large tumor suppressor homolog 2 (LATS2) gene overexpression on the proliferation and apoptosis of oral squamous cell carcinoma (OSCC).
Methods: Lentivirous particles were transferred into SCC-25 cell to upregulate LATS2 gene expression. Cell proliferation was detected by CCK-8 assay. Apoptosis was detected through flow cytometry. The expression changes of Bax, Bcl-2, and LATS2 were analyzed by Western blot.
Results: Gene transfection increased LATS2 expression. Compared with the control group and pEGFP-control group, SCC-25 cell proliferation in the pGFP-LATS2 group was inhibited, whereas the apoptosis ratio increased (P<0.05). Bcl-2 expression decreased, and Bax expression increased.
Conclusions: Overexpression of LATS2 could inhibit SCC-25 cell proliferation and induce apoptosis.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7039785 | PMC |
| http://dx.doi.org/10.7518/hxkq.2018.06.005 | DOI Listing |
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