A mild, metal-free, and multicomponent route for the preparation of N-acyl amidines from nitroalkene derivatives, dibromo amides, and amines has been developed that accesses an initial α,α-dibromonitroalkane intermediate that can undergo C-C bond cleavage. This protocol offers an alternative approach toward N-acyl amidines and features the rapid construction of amidine frameworks with high diversity and complexity. The procedure also accesses bisamidine and α,β-unsaturated amidines which are challenging targets by traditional methods.
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Article Synopsis
- * The complexes were analyzed and characterized through various techniques, including single-crystal X-ray diffraction, revealing a distorted square planar geometry with specific ligand interactions.
- * Cytotoxicity tests showed that the chloro-complex exhibited greater effectiveness against a leukemia cell line compared to the chemotherapy drug cisplatin, while being less toxic to healthy cells.
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