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| http://dx.doi.org/10.1002/ajh.25389 | DOI Listing |
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Plasma inflammatory and angiogenic protein profiling of patients with sickle cell disease.
Br J Haematol
January 2025
Department of Molecular Hematology, Sanquin Research and Landsteiner Laboratory, Amsterdam, the Netherlands.
Article Synopsis
- The study investigated inflammation and blood vessel growth in sickle cell disease (SCD) by analyzing plasma proteins from 57 SCD patients and 13 healthy controls using advanced technology.
- Fifty proteins showed significant differences between SCD patients and controls, particularly those related to blood vessel formation and immune responses.
- The results suggest that certain proteins increase during painful episodes, but can return to normal levels with effective treatments, which could help develop new therapies for SCD.
A contemporary review of the management strategies for sickle cell disease related ischaemic and stuttering priapism.
Int J Impot Res
December 2024
Department of Urology, Guy's & St Thomas' Hospital, London, UK.
Sickle cell disease is one of the most common autosomal recessive genetic disorders with 23% and over 70% of men with this condition, experiencing episodes of ischaemic priapism and stuttering priapism, respectively, with potentially severe consequences. The effective prevention of sickle cell disease induced ischaemic priapism and stuttering priapism requires a multidisciplinary and multimodal approach. A search of the English literature was performed utilising Pubmed® and Google Scholar to identify publications on contemporary and novel treatment options, with their associated treatment outcomes if available, that are utilised to prevent stuttering priapism episodes and hence a fulminant ischaemic priapism.
View Article and Find Full Text PDFInflammatory pathways and anti-inflammatory therapies in sickle cell disease.
Hemasphere
December 2024
Divisão de Hematologia, Hemoterapia e Terapia Celular Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo São Paulo Brazil.
Sickle cell disease (SCD) is a monogenic disease, resulting from a single-point mutation, that presents a complex pathophysiology and high clinical heterogeneity. Inflammation stands as a prominent characteristic of SCD. Over the past few decades, the role of different cells and molecules in the regulation of the inflammatory process has been elucidated.
View Article and Find Full Text PDFPractical guide for disease-modifying medication management of children and adolescents with sickle cell disease.
Hematology Am Soc Hematol Educ Program
December 2024
Department of Pediatrics, The Research Institute at Nationwide Children's Hospital, Columbus, OH.
Hydroxyurea has historically been the sole disease-modifying medication (DMM) for sickle cell disease (SCD). However, 3 newer DMMs, L-glutamine, voxelotor, and crizanlizumab, were approved for children and adolescents with SCD since 2017. Despite their emergence, treatment barriers, including access, affordability, and nonadherence, limit the optimization of DMMs in the clinical setting.
View Article and Find Full Text PDFNovel Pathway and Recent Advances for Targeting Sickle Cell Anemia through Novel Drug Delivery System.
Cardiovasc Hematol Agents Med Chem
December 2024
Department of Pharmacology, Rungta College of Pharmaceutical Science and Research, Bhilai, Chhattisgarh, 490023, India.
Red blood cells with sickle cell anemia (SCA) have an irregular shape, and it is a genetic blood condition that can cause several problems and shorten life expectancy. Traditional treatments have focused on symptom management, but recent advancements in drug delivery systems offer promising pathways for targeted therapies. This abstract explores novel approaches to combat SCA through innovative drug delivery systems, gene therapy, and new pharmaceutical interventions.
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