AI Article Synopsis
- Merkel cell carcinoma (MCC) is a rare but aggressive skin cancer often linked to the Merkel cell polyomavirus (MCPyV), and researchers aimed to explore the connection between Notch signaling and MCPyV status in relation to patient prognosis.
- In a study, samples from patients with either MCPyV-positive or negative MCC were analyzed for the expression of NOTCH1, NOTCH2, NOTCH3, and JAG1.
- The findings revealed that while NOTCH1 and NOTCH2 did not correlate with MCPyV status, higher levels of JAG1 were found in MCPyV-negative samples, and increased NOTCH3 expression was associated with better survival outcomes, indicating its role as a
Article Abstract
Background/aim: Merkel cell carcinoma (MCC) is a rare, aggressive, neuroendocrine skin cancer and most MCCs are related to infection with Merkel cell polyomavirus (MCPyV). Notch signaling modulates cell fate in various tissues including the skin during development and homeostasis, and its aberrant activity relates to onset and progression of various malignancies. Therefore, association of NOTCH1/ NOTCH2/NOTCH3/jagged 1 (JAG1) expression with MCPyV status and prognosis in MCC was investigated.
Materials And Methods: A total of 19 MCPyV-positive and 19 MCPyV-negative MCC samples from patients were stained immunohistochemically with antibodies against NOTCH1, NOTCH2, NOTCH3, and JAG1 and analyzed.
Results: Expression of NOTCH1 and NOTCH2 was not associated with MCPyV status or prognosis. However, higher JAG1 expression was found in MCPyV-negative than in MCPyV-positive MCC (p<0.001), and NOTCH3 expression was higher in MCPyV-positive MCC (p=0.062). Kaplan-Meier and multivariate analyses showed that patients with MCC with higher NOTCH3 expression had better overall survival than otherwise (p=0.001 and p=0.033, respectively).
Conclusion: Expression of NOTCH3, as a tumor suppressor, is an independent predictor of MCC outcome.
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| http://dx.doi.org/10.21873/anticanres.13114 | DOI Listing |
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