Background: The safety and efficacy of brain parenchyma biopsy during minimally invasive (MIS) intracerebral hemorrhage (ICH) clot evacuation has not been previously reported. The objective of this study was to establish the safety and diagnostic efficacy of brain biopsy during MIS ICH clot evacuation and to validate the modified Boston criteria as a predictor of cerebral amyloid angiopathy (CAA) in this cohort.
Methods: From October 2016 to March 2018, superficial and perihematomal biopsies were collected for 40 patients undergoing MIS ICH clot evacuation and analyzed by the pathology department to assess for various ICH etiologies. Additionally, the admission magnetic resonance imaging or computed tomography scan of each patient was analyzed and evaluated for the likelihood of a CAA etiology based on the modified Boston criteria. Student t test was used to analyze intergroup differences in continuous variables, and a 2-tailed Fisher exact test was used to determine intergroup differences of categorical variables, with significance set at P < 0.05.
Results: Two of the 40 patients (5%) experienced postoperative rebleed. Four of the 40 patients (10%) had evidence of CAA on biopsy. Patients with CAA on biopsy were older (P = 0.005) and had a higher prevalence of parietal lobe (P = 0.02) and occipital lobe (P = 0.001) hemorrhage. The modified Boston criteria had a sensitivity of 100% (95% confidence interval [CI], 39.6%-100%) and a specificity of 72.2% (95% CI, 54.6%-84.2%) for predicting CAA on biopsy.
Conclusions: Brain biopsy in MIS ICH clot evacuation is safe and allows for the diagnosis of various ICH etiologies.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8407056 | PMC |
| http://dx.doi.org/10.1016/j.wneu.2018.12.058 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Endoscopic surgery without decompressive craniectomy for large putaminal intracerebral hemorrhage: how I do it.
Acta Neurochir (Wien)
December 2024
Department of Neurosurgery, Liuzhou People's Hospital, Liuzhou, 545001, Guangxi Autonomous Region, China.
Background: Endoscopic hematoma evacuation is an efficient and secure minimally invasive procedure for intracerebral hemorrhages, characterized by a greater evacuation rate and reduced complications.
Method: Pure endoscopic surgery without decompressive craniectomy was used to remove the clot in individuals with large putaminal intracerebral hemorrhage. The intracranial pressure was monitored after surgery.
Case Report and Literature Review: A Severe Case of Blast-Related Traumatic Brain Injury.
Asian J Neurosurg
December 2024
Neurosurgery Department, Hospital Kuala Lumpur, Kuala Lumpur, Malaysia.
Article Synopsis
- Blast-related traumatic brain injuries (bTBIs) are increasingly impacting civilians due to terrorist activities and industrial incidents, presenting complex medical challenges.
- These injuries emerge from various causes including blast effects, flying debris, impacts from falling, and exposure to harmful substances like fire and gases.
- A reported case of severe bTBI involved a patient who suffered complications post-surgery, emphasizing the need for improved treatment methods and a collaborative care approach.
Intracerebral Hemorrhage.
Cerebrovasc Dis Extra
December 2024
Stroke Center and Department of Neurology, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Background: Compared to ischemic stroke, intracerebral hemorrhage (ICH) has higher mortality and more severe disability. Asian such as Chinese and Japanese and Mexican Americans, Latin Americans, African Americans, Native Americans has higher incidences than do white Americans. So, ICH is an important cerebrovascular disease in Asia.
View Article and Find Full Text PDFEvaluating transurethral resection of the prostate over twenty years: a systematic review and meta-analysis of randomized clinical trials.
World J Urol
November 2024
Desai Sethi Urology Institute, University of Miami, Miller School of Medicine, Miami, USA.
Article Synopsis
Dramatic Reanimation and Spontaneous Re-Canalization of a Fourth Ventricular Hemorrhage: "REVIVE" Phenomenon.
Neurohospitalist
October 2024
Departments of Neurological Surgery, Neurology and Critical care, Mayo Clinic, Jacksonville, Florida, USA.
Background: Intraventricular hemorrhage is a calamitous type of stroke where bleeding into the ventricular system can be defined as: primary, if confined within the ventricles; or secondary, due to intracerebral hemorrhage extending from adjacent parenchyma. Intraventricular blood clot can lead to secondary insult and inflammatory responses that culminates in hydrocephalus as the most common cause of death.
Purpose: THerein, we report a patient with a high modified Graeb scale and low Glasgow coma scale.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!