AI Article Synopsis
- The study aimed to explore how trans-resveratrol, a natural antioxidant found in fruits and plants, affects the growth of lymphocytes and the activity of macrophages in fish immune cells.
- It was discovered that trans-resveratrol suppressed the proliferation of blood B cells and T lymphocytes from organs, although a minor stimulatory effect was noted at low concentrations.
- The compound enhanced phagocytic activity and respiratory burst in macrophages, indicating its potential as an immunomodulator for enhancing innate immunity in fish.
Article Abstract
The objective of this study was to investigate the effect of trans-resveratrol, a potent antioxidant with anti-inflammatory and chemopreventive properties, naturally occurring in many fruits and plants on lymphocytes proliferation and also on macrophages metabolic and phagocytic activity. The aim of this study was to demonstrate the immunomodulatory effects of the compound on fish immunocompetent cells and determine the type of this interaction (immunosuppression or immunostimulation). Proliferative activity of lymphocytes was studied by MTT assay, and the respiratory burst was evaluated using the respiratory burst activity (RBA) test. Phagocytic killing was tested using the PKA test. The experiment have shown that trans-resveratrol suppressed blood B cells, while there was no significant influence on blood T lymphocytes. However, insignificant stimulatory effect occurred at the lowest concentration. In addition, the compound inhibited proliferation of T and B lymphocytes isolated from the organs. Importantly, trans-resveratrol caused stimulation of blood and organs macrophages phagocytic killing, and also increased the respiratory burst of macrophages isolated from organ. These results suggest a potential use of trans-resveratrol as an immunomodulator of innate immunity in fish. This is particularly important, as this kind of resistance plays leading role in protecting the body against infection. In comparison, adaptive immunity is slower and also much less precise.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305612 | PMC |
| http://dx.doi.org/10.5114/ceji.2018.80041 | DOI Listing |
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