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A Multiplex Polymerase Chain Reaction Assay for the Detection of Herpes Simplex Virus, Cytomegalovirus, and Varicella-Zoster Virus in Cerebrospinal Fluid.
Microorganisms
January 2025
School of Medicine and Health, Institute of Virology, Technical University of Munich/Helmholtz Munich, 81675 Munich, Germany.
Viral meningitis poses a significant clinical challenge due to its rapid onset and potential progression to life-threatening encephalitis. Early detection of treatable viral pathogens such as Herpes simplex virus (HSV), Cytomegalovirus (CMV), and Varicella-zoster virus (VZV) is essential for initiating appropriate therapies. However, multiplex PCRs for the rapid and simultaneous detection of these pathogens are scarce due to the complex PCR design and the elaborate validation process using cerebrospinal fluid samples.
View Article and Find Full Text PDFMetagenomic analysis identifying a polymicrobial pulmonary infection in a non-HIV immunocompromised patient: a case report.
BMC Pulm Med
January 2025
Central Laboratory, Liaocheng People's Hospital and Liaocheng School of Clinical Medicine, Shandong First Medical University, Liaocheng, Shandong, 252000, China.
Background: Polymicrobial pulmonary infections, common in immunocompromised patients, often manifest more severe symptoms than monomicrobial infections. Clinical diagnosis delays may lead to mortality, emphasizing the importance of fast and accurate diagnosis for these patients. Metagenomic next-generation sequencing (mNGS), as an unbiased method capable of detecting all microbes, is a valuable tool to identify pathogens, particularly in cases where infections are difficult to diagnosis using conventional methods.
View Article and Find Full Text PDFAccurate Multiplex qPCR Detection of Epstein-Barr Virus/Cytomegalovirus/BK Virus in Kidney Transplant Patients: Pilot Study.
Int J Mol Sci
November 2024
Department of Preventive Medicine and Interdisciplinarity (IX)-Microbiology, Faculty of Medicine, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.
Chronic kidney disease is a really important heath issue, and transplantation is an intervention that can greatly increase patient quality of life and survival. The aim of this study was to perform a comprehensive evaluation of the BK virus, CMV, and EBV in kidney transplant recipients (KTRs); to assess the prevalence of infections; and to test if our detection method would be feasible for use in follow-ups with KTRs. A total of 157 KTRs registered at the Clinical Hospital "Dr.
View Article and Find Full Text PDFCoinfection of cytomegalovirus and strongyloidiasis presenting as massive gastrointestinal bleeding in an immunocompromised host: a case report.
Front Med (Lausanne)
November 2024
Department of Gastroenterology, 108 Military Central Hospital, Hanoi, Vietnam.
Cytomegalovirus (CMV) infection is an opportunistic disease in immunocompromised patients that may appear without symptoms, with constitutional symptoms, or as a tissue-invasive disease. infection often manifests with non-specific symptoms; however, it can lead to severe malabsorption and extraintestinal dissemination by accelerated autoinfection. The coinfection of CMV and has rarely been reported, particularly with solely severe gastrointestinal bleeding.
View Article and Find Full Text PDFDeciphering the pathogen heterogeneity for precise diagnosis and personalized therapeutics of infections after kidney transplantation: insights from metagenomic next-generation sequencing.
Front Cell Infect Microbiol
November 2024
Department of Urology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Introduction: The aim of this study was to compare the detection performance of mNGS against that of conventional tests (CT) in patients suffering from infection after kidney transplantation.
Methods: A total of 138 samples from 85 kidney transplant patients with acute or chronic infections were simultaneously analyzed using mNGS and CT from July 2021 to August 2023.
Results: Compared with CT, mNGS demonstrated a higher sensitivity (95.
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