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Towards Meaningful Interpretation of Molecular Data: Insights Gained from HMMD Challenges in Detection for Future NGS Integration in Clinical Microbiology.
Diagnostics (Basel)
December 2024
Department of Laboratory Medicine, Seoul National University Bundang Hospital and Seoul National University College of Medicine, Seoul 03080, Republic of Korea.
With advancements in molecular diagnostics, including Highly Multiplexed Microbiological/Medical Countermeasure Diagnostic Devices (HMMDs) and the impending integration of Next-Generation Sequencing (NGS) into clinical microbiology, interpreting the flood of nucleic acid data in a clinically meaningful way has become a crucial challenge. This study focuses on the Luminex xTAG Gastrointestinal Pathogen Panel (GPP) for detection, evaluating the impact of MFI threshold adjustments on diagnostic accuracy and exploring the need for an "indeterminate" result category to enhance clinical utility in molecular diagnostics. A retrospective review of -positive cases detected via the Luminex xTAG GPP was conducted from June 2016 to November 2023.
View Article and Find Full Text PDFA qualitative descriptive study examining the impact of child-raising experience on Japanese family doctors.
J Gen Fam Med
January 2025
Background: The Patient-Centered Clinical Method (PCCM) plays an important role in family doctors' ability to communicate effectively with patients. Although the parenting experiences of healthcare providers can be utilized to communicate with patients, it is unclear how they contribute to family doctors' practice.
Methods: A qualitative descriptive study focusing on the parenting experiences of Japanese family doctors and their perceptions of how these experiences interfaced with their clinical practice of the PCCM was conducted.
North American Pilot of TBIconneCT: A Social Communication Intervention via Telehealth for Individuals With Traumatic Brain Injury and Their Conversation Partners.
Am J Speech Lang Pathol
January 2025
University of Sydney, New South Wales, Australia.
Purpose: The purpose of this pilot investigation was to identify formative feedback to guide the development of a North American version of the TBIconneCT program. A secondary purpose was to examine the feasibility of delivering the intervention by graduate students.
Method: Two cohorts of individuals with chronic brain injuries and their communication partners were recruited for a 10-week, modified TBIconneCT program delivered by graduate student clinicians via telehealth.
Professional judgement: a social practice perspective on a multiple mini-interview for specialty training selection.
BMC Med Educ
January 2025
Division of Learning and Teaching, Charles Sturt University, Bathurst, NSW, Australia.
Background: Interviewers' judgements play a critical role in competency-based assessments for selection such as the multiple-mini-interview (MMI). Much of the published research focuses on the psychometrics of selection and the impact of rater subjectivity. Within the context of selecting for entry into specialty postgraduate training, we used an interpretivist and socio-constructivist approach to explore how and why interviewers make judgments in high stakes selection settings whilst taking part in an MMI.
View Article and Find Full Text PDFA Socioecological Approach to Support the Transition to Adult Care for Youth With Medical Complexity: Family Perspectives and Recommendations.
Health Expect
February 2025
School of Nursing, McMaster University, Hamilton, Ontario, Canada.
Introduction: The transition from paediatric to adult health care (i.e., 'health care transition') poses many challenges for youth with medical complexity (YMC) and their families.
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