AI Article Synopsis
- Solid-state nanopores can read the 3D shapes of molecules and translate that information into electrical signals, enhancing the study of molecular structures.
- This research presents a high-resolution nanopore system capable of identifying DNA nanostructures, distinguishing between hairpins with just an 8 base pair difference.
- The platform allows for the reading of numerous DNA hairpins linked to a DNA carrier for digital information storage, enabling a data library of up to 500 molecules, with promising scalability through additional DNA carriers.
Article Abstract
Solid-state nanopores are powerful tools for reading the three-dimensional shape of molecules, allowing for the translation of molecular structure information into electric signals. Here, we show a high-resolution integrated nanopore system for identifying DNA nanostructures that has the capability of distinguishing attached short DNA hairpins with only a stem length difference of 8 bp along a DNA double strand named the DNA carrier. Using our platform, we can read up to 112 DNA hairpins with a separating distance of 114 bp attached on a DNA carrier that carries digital information. Our encoding strategy allows for the creation of a library of molecules with a size of up to 5 × 10 (2) that is only built from a few hundred types of base molecules for data storage and has the potential to be extended by linking multiple DNA carriers. Our platform provides a nanopore- and DNA nanostructure-based data storage method with convenient access and the potential for miniature-scale integration.
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| http://dx.doi.org/10.1021/acs.nanolett.8b04715 | DOI Listing |
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