We established the vibration governing equation for a magnetoelastic (ME) biosensor with target loading in liquid. Based on the equation, a numerical simulation approach was used to determine the effect of the target loading position and viscous damping coefficient on the node ("blind points") and mass sensitivity () of an ME biosensor under different order resonances. The results indicate that viscous damping force causes the specific nodes shift but does not affect the overall variation trend of as the change of target loading position and the effect on Sm gradually reduces when the target approaches to the node. In addition, decreases with the increase of viscous damping coefficient but the tendency becomes weak at high-order resonance. Moreover, the effect of target loading position on decreases with the increase of viscous damping coefficient. Finally, the results provide certain guidance on improving the mass sensitivity of an ME biosensor in liquid by controlling the target loading position.
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http://dx.doi.org/10.3390/s19010067 | DOI Listing |
Colloids Surf B Biointerfaces
January 2025
The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510405, PR China; Guangdong Clinical Research Academy of Chinese Medicine, Guangzhou 510130, PR China; Guangzhou University of Chinese Medicine Postdoctoral Research Station, Guangzhou 510130, PR China. Electronic address:
Intervertebral disc degeneration (IVDD), an age-associated degenerative condition, significantly contributes to low back pain, thereby adversely affecting individual health and quality of life, while also imposing a substantial societal burden. Baicalein, a natural flavonoid derived from Scutellaria baicalensis Georgi, demonstrates a range of pharmacological activities, including antioxidant, anti-inflammatory, anti-tumor, and antibacterial properties. This positions it as a promising candidate for the treatment of IVDD through intradiscal drug delivery.
View Article and Find Full Text PDFACS Appl Mater Interfaces
January 2025
School of Physical Science and Technology, ShanghaiTech University, Shanghai 201210, China.
In this study, we synthesized CeO possessing an open pore structure and verified its structural differences compared to CeO lacking such an open pore structure. Using these two CeO samples as catalyst supports and loading them with Pd metals, a series of characterizations were carried out on the resultant catalysts to analyze their structures and properties meticulously. We have elucidated the influence of the open pore structure on the loading position of Pd.
View Article and Find Full Text PDFObjective: Aim: Study the mechanism of interaction between the 'sacroiliac joint - screw' system and determine the optimal parameters of the stabilizing structure, the strength of the system connection through computer modeling, and anatomical-biomechanical experiment.
Patients And Methods: Materials and Methods: The optimal parameters of the stabilizing structure for the sacroiliac joint were calculated using software package MathCAD. To validate the results of the numerical modeling, corresponding investigations of mechanical characteristics and determination of stiffness of the studied systems were conducted by an upgraded testing stand, TIRAtest-2151.
Mater Today Bio
February 2025
Anhui University of Chinese Medicine, Hefei, 230012, China.
The therapeutic effect of immune checkpoint inhibitors (ICIs) in triple-negative breast cancer (TNBC) is unsatisfactory. The immune "cold" microenvironment caused by tumor-associated fibroblasts (TAFs) has an adverse effect on the antitumor response. Therefore, in this study, mixed cell membrane-coated porous magnetic nanoparticles (PMNPs) were constructed to deliver salvianolic acid B (SAB) to induce an antitumor immune response, facilitating the transition from a "cold" to a "hot" tumor and ultimately enhancing the therapeutic efficacy of immune checkpoint inhibitors.
View Article and Find Full Text PDFClin Biomech (Bristol)
January 2025
Department of Veterans Affairs, Center for Limb Loss and MoBility, Seattle, WA, USA; Department of Mechanical Engineering, University of Washington, Seattle, WA, USA. Electronic address:
Background: Ambulatory individuals with lower limb amputations often face challenges with body support, body propulsion, and balance control. Carrying an infant, toddler, backpack, or other load can exacerbate these challenges and highlights the importance of prescribing the most suitable prosthetic foot. The aim of this study was to examine the influence of five different prosthetic feet on walking performance during various load carriage conditions.
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