[Interrelation of endothelial dysfunction and parameters of erythrocyte membrane oxygenation in patients with atrial fibrillation, after cardioembolic stroke.].

The aim of our work was to study the relationship between endothelial dysfunction (ED) and erythrocyte membrane oxygenation parameters in patients over 60 years of age with atrial fibrillation (AF) within a year after a cardioembolic stroke. In the period from 01 January 2014 to 30 January 2015. the authors performed a prospective observational study in which, after scrinia by the random number generated 4 groups of patients after stroke: group 1 (n=65) with newly diagnosed AF (ndAF), group 2 (n=65) - paroxysmal form of AF group 3 (n=65) is a persistent form of AF and group 4 (n=65) with permanent form of AF. The duration of observation is 1 year and conducted 3 visits (V): estimation of the parameters of erythrocyte membranes (coefficientpossible the erythrocyte membrane was calculated - dy1/dy2) by the method of laser interference microscopy, the markers of ED - von Willebrand factor, antithrombin III (at III) and plasminogen. Results: a high mortality rate was found during the year after stroke in patients of all groups, and especially in patients with ndAF, where ED disorders and parameters of erythrocyte membrane oxygenation were most significantly revealed. The obtained data allow us to say that in patients with ndAF, after stroke, older than 60 years, there is a relationship between ED and the formation of «hard» red blood cells with reduced dy1/dy2.