Blood levels of Maprotiline were analysed and their relationship to the clinical response was examined in 89 depressed inpatients, according DSM III criteria for Major Depressive Episode, given the drug treatment for 3 weeks. Maprotiline produced marked decreases in mean MADRS and COVI scale scores by the end of treatment. On day 21, no correlation between blood levels of Maprotiline and MADRS or COVI scores were found when all patients were considered. Nevertheless, significant correlations were observed on day 14 (r = .22; p less than .05 for MADRS and r = .23; p less than .05 for COVI scale). In addition, a significant correlation between MADRS or COVI scale scores and Maprotiline blood levels were observed on days 14 and 21 in subgroups of young patients, severe depression (high scores to clinical global investigations), during of at least 3 months, treated without other drug than Maprotiline and good responders.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Psychiatric morbidity, pain perception, and functional status of chronic pain patients in palliative care.
Indian J Palliat Care
September 2013
Institute of Palliative Medicine, Kozhikode, Kerala, India.
Context: Psychological factors, such as that exist when we experience pain, can profoundly alter the strength of pain perception.
Aim: The study aims to estimate the prevalence of psychiatric disorders, and its association with perception of pain and functional status in chronic patients in palliative care.
Materials And Methods: The sample was selected via simple randomisation and post consent were assessed using (1) a semi- structured questionnaire to elicit socio-demographic information and medical data (2) Brief Pain Inventory (3) ICD-10 Symptom Checklist (4) ICD-10-Diagnostic Criteria for Research (DCR) (5) Montgomery Asberg Depression Rating Scale (MADRS) (6) Covi Anxiety Rating Scale (7) Karnofsky Performance Status Scale.
Psychopathology in amyotrophic lateral sclerosis: a preliminary study with 27 ALS patients.
Amyotroph Lateral Scler Other Motor Neuron Disord
December 2005
Laboratory of Clinical Psychology and Psychopathology, University Paris Descartes, F-92774 Boulogne Billancourt, Paris, France.
Considering the few studies published on the psychopathology of ALS patients, we carried out a preliminary study evaluating depression, anxiety, emotional reactions and coping strategies in such patients. Twenty-seven ALS patients were included and evaluated using a semi-structured interview, after which they were asked to complete a questionnaire. The rater asessed the DSM-IV criteria for a major depressive episode, dysthymia and generalized anxiety, using the MADRS scale for depression, the Covi anxiety scale and the Depressive Mood scale.
View Article and Find Full Text PDFRelationship between body-mass index and depressive symptoms in patients with major depression.
Eur Psychiatry
March 2003
Département de Pharmacologie, Pitié-Salpêtrière University Hospital, 47, Bd de l'Hôpital, 75013 Paris, France.
Background: Appetite and weight changes are commonly occurring symptoms of depressive illness. The occurrence of these symptoms may not only be related to depressive mood but may also be related to body weight.
Aim: To examine the relationship between symptoms of depression and body weight.
Tianeptine and fluoxetine in major depression: a 6-week randomised double-blind study.
Hum Psychopharmacol
August 2002
Department of Psychiatry, Comenius University, Bratislava, Slovakia.
In a 6-week, multicentre, randomised, double-blind controlled study, tianeptine (37.5 mg/day) and fluoxetine (20 mg/day) were compared for efficacy and safety in 178 patients with major depression. No significant difference was shown between the two drugs, either in terms of efficacy (MADRS, CGI, COVI) or in terms of safety, except for the CGI 'severity of illness' which was lower at the end point with tianeptine than with fluoxetine.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!