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3,5-Dicaffeoyl-Epi-Quinic Acid Isolated from Edible Halophyte Inhibits Adipogenesis via AMPK/MAPK Pathway in 3T3-L1 Adipocytes. | LitMetric

3,5-Dicaffeoyl-Epi-Quinic Acid Isolated from Edible Halophyte Inhibits Adipogenesis via AMPK/MAPK Pathway in 3T3-L1 Adipocytes.

Evid Based Complement Alternat Med

Department of Food and Nutrition, College of Medical and Life Sciences, Silla University, Busan 46958, Republic of Korea.

Published: November 2018

AI Article Synopsis

Article Abstract

is an edible halophyte that has been suggested to possess various health benefits. In the present study, 3,5-dicaffeoyl-epi-quinic acid (DEQA) isolated from was tested for its ability to prevent adipogenesis in 3T3-L1 cells. Also, the molecular mechanisms by which DEQA affects differentiation of 3T3-L1 cells were investigated. The introduction of DEQA to differentiating 3T3-L1 preadipocytes resulted in suppressed adipogenesis and lowered expression of adipogenesis-related factors, PPAR, C/EBP, and SREBP-1c. Treatment of 3T3-L1 adipocytes with DEQA notably decreased the levels of phosphorylated p38, ERK, and JNK. In addition, presence of DEQA upregulated the levels of both inactive and phosphorylated adenosine monophosphate-activated protein kinase (AMPK) and its substrate, acetyl-CoA carboxylase (ACC). Taken together, current results indicated that DEQA exhibited a significant antiadipogenesis activity by activation of AMPK and downregulation of MAPK signal pathways in 3T3-L1 preadipocytes.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280297PMC
http://dx.doi.org/10.1155/2018/8572571DOI Listing

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