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Treat-to-Target Strategy for Asian Patients with Early Rheumatoid Arthritis: Result of a Multicenter Trial in Korea. | LitMetric

AI Article Synopsis

  • The study assessed the effectiveness of a treat-to-target (T2T) approach in managing early rheumatoid arthritis (RA) among Asian patients in Korea, involving 346 participants over one year.
  • Patients were divided into two groups: those under the T2T strategy, where treatments were adjusted to achieve specific disease activity targets, and those receiving standard care.
  • Results showed that the T2T group had significantly better outcomes, including higher rates of remission and improved physical function, supporting the use of T2T in early RA treatment.

Article Abstract

Background: To evaluate the therapeutic benefits of the treat-to-target (T2T) strategy for Asian patients with early rheumatoid arthritis (RA) in Korea.

Methods: In a 1-year, multicenter, open-label strategy trial, 346 patients with early RA were recruited from 20 institutions across Korea and stratified into 2 groups, depending on whether they were recruited by rheumatologists who have adopted the T2T strategy (T2T group) or by rheumatologists who provided usual care (non-T2T group). Data regarding demographics, rheumatoid factor titer, anti-cyclic citrullinated peptide antibody titer, disease activity score of 28 joints (DAS28), and Korean Health Assessment Questionnaire (KHAQ) score were obtained at baseline and after 1 year of treatment. In the T2T group, the prescription for disease-modifying antirheumatic drugs was tailored to the predefined treatment target in each patient, namely remission (DAS28 < 2.6) or low disease activity (LDA) (2.6 ≤ DAS28 < 3.2).

Results: Data were available for 163 T2T patients and 162 non-T2T patients. At the end of the study period, clinical outcomes were better in the T2T group than in the non-T2T group (LDA or remission, 59.5% vs. 35.8%; < 0.001; remission, 43.6% vs. 19.8%; < 0.001). Compared with non-T2T, T2T was also associated with higher rate of good European League Against Rheumatism response (63.0% vs. 39.8%; < 0.001), improved KHAQ scores (-0.38 vs. -0.13; = 0.008), and higher frequency of follow-up visits (5.0 vs. 2.0 visits/year; < 0.001).

Conclusion: In Asian patients with early RA, T2T improves disease activity and physical function. Setting a pre-defined treatment target in terms of DAS28 is recommended.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300659PMC
http://dx.doi.org/10.3346/jkms.2018.33.e346DOI Listing

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