A PHP Error was encountered

Severity: Warning

Message: file_get_contents(https://...@pubfacts.com&api_key=b8daa3ad693db53b1410957c26c9a51b4908&a=1): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests

Filename: helpers/my_audit_helper.php

Line Number: 176

Backtrace:

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 176
Function: file_get_contents

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 250
Function: simplexml_load_file_from_url

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 3122
Function: getPubMedXML

File: /var/www/html/application/controllers/Detail.php
Line: 575
Function: pubMedSearch_Global

File: /var/www/html/application/controllers/Detail.php
Line: 489
Function: pubMedGetRelatedKeyword

File: /var/www/html/index.php
Line: 316
Function: require_once

Leptin Gene G2548A Polymorphism among Mongolians with Metabolic Syndrome. | LitMetric

Leptin Gene G2548A Polymorphism among Mongolians with Metabolic Syndrome.

Med Sci (Basel)

Department of Biochemistry and Laboratory Medicine, School of Biomedicine, Mongolian National University of Medical Sciences, Ulaanbaatar 14210, Mongolia.

Published: December 2018

Metabolic syndrome (MetS) corresponds with multiple risk factors. Many studies have indicated that MetS significantly increases the risk of cardiovascular diseases and type 2 diabetes (T2D). The prevalence of MetS was estimated to be one third of the general Mongolian population in 2015. The purpose of our study was to determine polymorphisms of the (Leptin) and (Leptin receptor) genes that show susceptibility to MetS and to predict the genetic risk of MetS. We selected 160 cases with MetS and 144 with healthy controls. The G2548A polymorphism of the gene and the A668G (Q223R) polymorphism of the gene were genotyped using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The results of the regression analysis showed that the 2548 amino acids (AA) of gene carriers had increased incidences of MetS (OR = 3.23; = 0.035), and the combined genotype AA/AA of and gene polymorphisms was related to the development of MetS (OR = 3.73; = 0.047). Patients with MetS who were 2548A allele carriers had an increased concentration of serum leptin ( = 0.011). Moreover, G2548A of polymorphism was associated with elevated body mass index (BMI) and fasting blood glucose (FBG) in the case group. Our results confirm that the G2548A loci is the independent risk factor of MetS.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359323PMC
http://dx.doi.org/10.3390/medsci7010003DOI Listing

Publication Analysis

Top Keywords

g2548a polymorphism
12
mets
10
metabolic syndrome
8
polymorphism gene
8
carriers increased
8
polymorphism
5
leptin
4
leptin gene
4
g2548a
4
gene g2548a
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!