AI Article Synopsis
- - The study assessed a new formulation of chlorhexidine gluconate (CHG) skin prep with a film-forming copolymer to see how effective it is at killing bacteria before surgery, even when contaminants like blood are present.
- - In tests, this formulation achieved a significant reduction (99.999%) in bacteria and maintained its effectiveness in the presence of serum, with no evidence of developing resistance to CHG or cross-resistance with antibiotics.
- - The findings indicate that the new CHG formulation is both effective as an antiseptic and does not pose risks for antibiotic resistance, making it a promising option for surgical skin prep.
Article Abstract
Objectives: Chlorhexidine gluconate (CHG) is routinely used for skin antisepsis before surgery. Its activity may be affected by formulation ingredients and the presence of organic matter such as blood and proteins. This in vitro study was designed to evaluate the antimicrobial activity of a new CHG skin prep containing a film-forming copolymer, and detect its potential for developing resistance and the potential for cross-resistance to antibiotics after CHG exposure.
Methods: Antimicrobial activity was evaluated in the presence and absence of serum in an in vitro time-kill study. Emergence of resistance to CHG and cross-resistance with antibiotic procedures were performed in vitro using 10 repository isolates from eight species and eight clinical isolate strains equal to the repository isolate strains (four isolates, two resistant and two non-resistant per species).
Results: A 5 log reduction (99.999%) for all organisms was observed using the copolymer formulation. The activity remained unchanged in the presence of serum. The minimum inhibitory concentration (MIC) did not increase for any of the strains evaluated for emergence of resistance. In addition, there was no change in MIC related to cross-resistance observed for any of the organism/antibiotic combinations tested.
Conclusions: These results suggest that the film-forming copolymer and the tint in the new CHG skin prep did not interfere with antimicrobial efficacy, even in the presence of an organic soil load, and that the tested formulations showed no potential for developing resistance or cross-resistance with antibiotics.
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| http://dx.doi.org/10.1016/j.jgar.2018.12.008 | DOI Listing |
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