Hepatocellular carcinomas (HCCs) frequently recur despite initial successful surgical resection or local ablation therapy. Diagnostic methods for small HCCs have improved with the introduction of gadoxetic acid-enhanced liver magnetic resonance imaging and diffusion-weighted imaging (DWI). Currently, sub-centimeter recurrent nodules showing typical hallmark imaging findings of HCC are frequently detected in patients with a treatment history for HCC. With five typical magnetic resonance findings, including arterial enhancement, washout on portal or transitional phase, high signal intensity on both T2-weighted image and DWI, and low signal intensity on hepatobiliary phase, sub-centimeter recurrent HCC can be diagnosed with high accuracy. Although more information is needed to determine the treatment of choice, local ablation therapy under fusion imaging and/or contrast-enhanced ultrasound guidance or cone-beam computed tomography-guided chemoembolization seem to be promising as they are effective and safe for the management of sub-centimeter recurrent HCCs.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295838 | PMC |
| http://dx.doi.org/10.3748/wjg.v24.i46.5215 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Recurrent Systemic Embolization From Bicuspid Aortic Valve Endocarditis in the Setting of Anti-coagulation Use.
Cureus
November 2024
Infectious Diseases, Southern Illinois University School of Medicine, Springfield, USA.
Article Synopsis
- Infective endocarditis (IE) is a serious condition with high mortality rates, especially in patients with abnormal heart valves like bicuspid aortic valves (BAV).
- A 22-year-old female initially hospitalized for splenic infarction was later diagnosed with IE after presenting symptoms of acute toe ischemia and showing vegetations on her aortic valve.
- The case highlights the importance of early detection and treatment of IE, especially in young patients, emphasizing the need to avoid anti-coagulation to prevent complications like embolic events.
Primary splenic multicystic peritoneal mesothelioma in a young healthy male.
J Surg Case Rep
October 2023
Department of Surgery, Johns Hopkins School of Medicine, 1800 Orleans Street, Baltimore, MD 21287, United States.
Multicystic peritoneal mesothelioma (BMPM) is a rare, usually benign tumor that arises from peritoneal mesothelial cells that most commonly occurs in women of reproductive age. Pathogenesis of these tumors is thought to come from chronic inflammation from prior surgery, endometriosis, trauma, or recurrent peritonitis. Here we report a case of primary splenic BMPM in a 20-year-old male with no past medical or surgical history and without any typical risk factors for this condition.
View Article and Find Full Text PDFGlypican-3 targeted positron emission tomography detects sub-centimeter tumors in a xenograft model of hepatocellular carcinoma.
EJNMMI Res
April 2023
Department of Surgery, University of Washington School of Medicine, 1959 NE Pacific Street, Health Sciences Bldg. Room BB-442, Box 356410, Seattle, WA, 98195-6410, USA.
Article Synopsis
- Early recurrence of hepatocellular carcinoma (HCC) after surgery is common and worsened by ineffective imaging, which can miss treatment chances.
- This study tested a zirconium-89 radiolabeled antibody targeting glypican-3 (GPC3) in mice to improve detection of small HCC tumors using PET imaging.
- The results showed that the Zr-αGPC3 had 100% sensitivity in identifying tumors as small as 330 μm, but had a specificity of only 60%, indicating that while it effectively detects tumors, it may also misidentify some non-tumor tissues.
Durable headache relief following endoscopic endonasal resection of sub-centimeter Rathke cleft cysts in medically refractory patients.
Acta Neurochir (Wien)
August 2023
Department of Neurosurgery, Weill Cornell Medicine and New York Presbyterian Hospital, New York, NY, USA.
Background: The most common presenting symptom in patients with both small and large Rathke cleft cysts (RCC) is headache (H/A). It is well established that patients with large RCC can have significant symptomatic improvement after cyst drainage. However, patients with small RCC (≤ 1 cm) are rarely operated on, even if they present with debilitating H/A.
View Article and Find Full Text PDFSclerosing Mesenteritis: A Rare Cause of Abdominal Pain.
Cureus
August 2022
Internal Medicine, Marshall University Joan C. Edwards School of Medicine, Huntington, USA.
Sclerosing mesenteritis (SM) is a rare inflammatory fibrotic disease of the small intestine mesenteric fat often discovered incidentally on a CT scan. Clinical manifestations depend on the mass effect on the viscera and vessels. The most common symptoms are abdominal pain, bloating, and nausea.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!